ReviewCurrent opinion in chemical biology2009
Computational tools for designing and engineering biocatalysts.
Review in Current opinion in chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- X-ray analysis of complexes of carbonic anhydrase II with 1,3-oxazole-containing sulfonamide derivatives elucidates the structural basis for their exceptionally high inhibitory potency.Acta crystallographica. Section F, Structural biology communications · 2026Article
- Accurate predictions of protein mutational effects accelerated with a hybrid-topology free energy protocol.Communications chemistry · 2025Article
- A Three-Module Machine Learning Framework for Protein Sequence- and Temperature-DependentACS synthetic biology · 2025Article
- A Machine Learning Study on the Thermostability Prediction of (R)-BioMed research international · 2021Article
- Article
- MinimalistACS catalysis · 2019Article
- Holistic engineering of Cal-A lipase chain-length selectivity identifies triglyceride binding hot-spot.PloS one · 2019Article
- A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes.Scientific reports · 2018Article
- Application of fourier transform and proteochemometrics principles to protein engineering.BMC bioinformatics · 2018Article
- Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.Molecular cell · 2018Article
- A review of computational tools for design and reconstruction of metabolic pathways.Synthetic and systems biotechnology · 2017Review
- Selection platforms for directed evolution in synthetic biology.Biochemical Society transactions · 2016Review
- Machine learning assisted design of highly active peptides for drug discovery.PLoS computational biology · 2015Article
- Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Chemical Society reviews · 2015Review
- Protein design for pathway engineering.Journal of structural biology · 2014Review
- Engineering the acyltransferase substrate specificity of assembly line polyketide synthases.Journal of the Royal Society, Interface · 2013Review
- Quantum chemistry as a tool in asymmetric biocatalysis: limonene epoxide hydrolase test case.Angewandte Chemie (International ed. in English) · 2013Article
- Biocatalyst development by directed evolution.Bioresource technology · 2012Review
- Recent advances in rational approaches for enzyme engineering.Computational and structural biotechnology journal · 2012Review
- Computer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein Engineering.Computational and structural biotechnology journal · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current computational tools to assist experimentalists for the design and engineering of proteins with desired catalytic properties are reviewed. The applications of these tools for de novo design of protein active sites, optimization of substrate access and product exit pathways, redesign of protein-protein interfaces, identification of neutral/advantageous/deleterious mutations in the libraries from directed evolution and stabilization of protein structures are described. Remarkable progress is seen in de novo design of enzymes catalyzing a chemical reaction for which a natural biocatalyst does not exist. Yet, constructed biocatalysts do not match natural enzymes in their efficiency, suggesting that more research is needed to capture all the important features of natural biocatalysts in theoretical designs.
Indexed as
Identifiers
19297237What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.