ReviewCurrent rheumatology reports2009
Counterpoint: Hydroxyapatite crystal deposition is not intimately involved in the pathogenesis and progression of human osteoarthritis.
Review in Current rheumatology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Cathepsin K Inhibitors as Potential Drugs for the Treatment of Osteoarthritis.International journal of molecular sciences · 2025Review
- Prevalence of intra-articular mineralization on knee computed tomography: the multicenter osteoarthritis study.Osteoarthritis and cartilage · 2023Article
- The role of Interleukin-1 receptor antagonist as a treatment option in calcium pyrophosphate crystal deposition disease.Molecular biology reports · 2021Review
- Detection of calcium pyrophosphate dihydrate crystals in knee meniscus by dual-energy computed tomography.Journal of orthopaedic surgery and research · 2018Article
- Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models.Biochimica et biophysica acta. General subjects · 2018Review
- Rapidly Progressive Osteoarthritis: a Review of the Clinical and Radiologic Presentation.Current rheumatology reports · 2017Review
- Revisiting spatial distribution and biochemical composition of calcium-containing crystals in human osteoarthritic articular cartilage.Arthritis research & therapy · 2013Article
- Phosphocitrate is potentially a disease-modifying drug for noncrystal-associated osteoarthritis.BioMed research international · 2013Article
- The Therapeutic Potential of Exogenous Adenosine Triphosphate (ATP) for Cartilage Tissue Engineering.Cartilage · 2012Article
- NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The role of uric acid and other crystals in osteoarthritis.Current rheumatology reports · 2010Review
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association of hydroxyapatite deposition with osteoarthritis pathogenesis and progression remains controversial, even after decades of study. Hydroxyapatite crystals are found in osteoarthritis in advanced disease only. Even then, hydroxyapatite crystals are found in such small amounts that special analytical techniques are required to detect the crystals. Further, the osteoarthritic joint fluid appears noninflammatory, suggesting that such hydroxyapatite crystals have very small effect on the pathologic process. Formal histopathologic evidence is scant, but hydroxyapatite crystal deposition within osteoarthritic synovium or cartilage is a rare event. Hydroxyapatite crystals may be present at end-stage osteoarthritis, but in insufficient amounts to contribute significantly to osteoarthritis pathogenesis or progression. This review critically examines the evidence from osteoarthritic synovial fluids, imaging, and histopathology to determine whether the well-characterized in vitro cellular reactions to hydroxyapatite apply to the pathogenesis of human osteoarthritis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.