ArticleCurrent rheumatology reports2009
Point: Hydroxyapatite crystal deposition is intimately involved in the pathogenesis and progression of human osteoarthritis.
Article in Current rheumatology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Osteoarthritis: molecular pathogenesis and potential therapeutic options.Signal transduction and targeted therapy · 2026Review
- Article
- New role of calcium-binding fluorescent dye alizarin complexone in detecting permeability from articular cartilage to subchondral bone.FASEB bioAdvances · 2024Article
- Lysosomal destabilization: A missing link between pathological calcification and osteoarthritis.Bioactive materials · 2024Article
- The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis.International journal of molecular sciences · 2023Review
- 3D analysis and grading of calcifications from ex vivo human meniscus.Osteoarthritis and cartilage · 2023Article
- Hydroxyapatite Particles Induced Modulation of Collagen Expression and Secretion in Primary Human Dermal Fibroblasts.International journal of nanomedicine · 2020Article
- Dexmedetomidine inhibits the NF-κB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats.Pharmaceutical biology · 2019Article
- Calcium-Phosphate Crystals Promote RANKL Expression via the Downregulation of DUSP1.Molecules and cells · 2019Article
- Detection of calcium pyrophosphate dihydrate crystals in knee meniscus by dual-energy computed tomography.Journal of orthopaedic surgery and research · 2018Article
- Macrophage Recognition of Crystals and Nanoparticles.Frontiers in immunology · 2018Review
- Article
- Gout and risk of knee replacement for severe knee osteoarthritis in the Singapore Chinese Health Study.Osteoarthritis and cartilage · 2017Article
- Rapidly Progressive Osteoarthritis: a Review of the Clinical and Radiologic Presentation.Current rheumatology reports · 2017Review
- Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells.Arthritis research & therapy · 2017Article
- Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis.Frontiers in pharmacology · 2017Article
- [MALDI mass spectrometry of the meniscus. Objectification of morphological findings].Zeitschrift fur Rheumatologie · 2015Article
- The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive.The Journal of rheumatology · 2015Review
- Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction.Arthritis research & therapy · 2014Article
- Revisiting spatial distribution and biochemical composition of calcium-containing crystals in human osteoarthritic articular cartilage.Arthritis research & therapy · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cause of osteoarthritis (OA), the most common form of arthritis, is most likely multifactorial. No drug exists to slow the progression or reverse OA disease progression. Ample data support a key role of calcium-containing crystals, such as hydroxyapatite, in OA pathogenesis. The presence of these crystals, far higher in OA than in any other form of arthritis, correlates with the degree of radiographic degeneration. Calcium-containing crystals have potent biologic effects in vitro that emphasize their pathogenic potential. OA-associated matrix and chondrocyte alterations play an intimate role in the crystal deposition process. A major difficulty has been the lack of a simple technique for crystal identification in affected joints. Enhanced effort is needed to establish calcium-containing crystals as a therapeutic target in OA, as current data suggest an intimate association in its pathogenesis and progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.