ReviewAnnual review of public health2009
Adaptive designs for randomized trials in public health.
Review in Annual review of public health, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01526265 (Way to Quit - Comparative Efficacy, Acceptance and Effectiveness of Health Incentive Structures), which is not on this map. Cited by 76 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Way to Quit - Comparative Efficacy, Acceptance and Effectiveness of Health Incentive Structures
Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design.BMC medicine · 2018Guideline
- Dissemination and implementation of evidence-based practices for child and adolescent mental health: a systematic review.Journal of the American Academy of Child and Adolescent Psychiatry · 2013Pooled it
- Whose knowledge counts? Involving communities in intervention and trial design using community conversations.Trials · 2023Trial
- Effect of the Wingman-Connect Upstream Suicide Prevention Program for Air Force Personnel in Training: A Cluster Randomized Clinical Trial.JAMA network open · 2020Trial
- Efficacy of a Spatial Repellent for Control of Malaria in Indonesia: A Cluster-Randomized Controlled Trial.The American journal of tropical medicine and hygiene · 2020Trial
- Evaluation of Store Environment Changes of an In-Store Intervention to Promote Fruits and Vegetables in Latino/Hispanic-Focused Food Stores.International journal of environmental research and public health · 2019Trial
- Trial
- Improving and sustaining delivery of CPT for PTSD in mental health systems: a cluster randomized trial.Implementation science : IS · 2017Trial
- Randomized trial of four financial-incentive programs for smoking cessation.The New England journal of medicine · 2015Trial
- Evaluation of two implementation strategies in 51 child county public service systems in two states: results of a cluster randomized head-to-head implementation trial.Implementation science : IS · 2014Trial
- Community-based implementation and effectiveness in a randomized trial of a risk reduction intervention for HIV-serodiscordant couples: study protocol.Implementation science : IS · 2014Trial
- Study protocol: a dissemination trial of computerized psychological treatment for depression and alcohol/other drug use comorbidity in an Australian clinical service.BMC psychiatry · 2012Trial
- An outcome evaluation of the Sources of Strength suicide prevention program delivered by adolescent peer leaders in high schools.American journal of public health · 2010Trial
- The first 7 days of a quit attempt predicts relapse: validation of a measure for screening medications for nicotine dependence.Journal of addiction medicineTrial
- What scientific inferences can be made with randomized implementation rollout trials.Implementation science : IS · 2025Article
- Evaluating digital intervention approaches for supporting immigrant women with intimate partner violence experiences: Findings from the It's weWomen plus sequential multiple assignment randomized trial (SMART).Contemporary clinical trials communications · 2025Article
- Evidence-Based Approaches to Quality Improvement: A Narrative Review of Integrating Bayesian Adaptive Trials Into Health Services.Journal of evaluation in clinical practice · 2025Review
- Adaptive designs in critical care trials: a simulation study.BMC medical research methodology · 2023Article
- Rationale and design for Healthy Hearts for Michigan (HH4M): A pragmatic single-arm hybrid effectiveness-implementation study.Contemporary clinical trials communications · 2023Article
- Impact of Sources of Strength on adolescent suicide deaths across three randomized trials.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2023Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
In this article, we present a discussion of two general ways in which the traditional randomized trial can be modified or adapted in response to the data being collected. We use the term adaptive design to refer to a trial in which characteristics of the study itself, such as the proportion assigned to active intervention versus control, change during the trial in response to data being collected. The term adaptive sequence of trials refers to a decision-making process that fundamentally informs the conceptualization and conduct of each new trial with the results of previous trials. Our discussion below investigates the utility of these two types of adaptations for public health evaluations. Examples are provided to illustrate how adaptation can be used in practice. From these case studies, we discuss whether such evaluations can or should be analyzed as if they were formal randomized trials, and we discuss practical as well as ethical issues arising in the conduct of these new-generation trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.