ArticleACS nano2009
Rational selection of gold nanorod geometry for label-free plasmonic biosensors.
Article in ACS nano, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Enhanced Refractive Index Sensitivity of Linearly Assembled Gold Nanoantennae for Biosensing Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Conventional and cutting-edge advances in plant virus detection: emerging trends and techniques.3 Biotech · 2025Review
- Calligraphy of Nanoplasmonic Bioink-Based Multiplex Immunosensor for Precision Immune Monitoring and Modulation.ACS applied materials & interfaces · 2023Article
- Balancing detectivity and sensitivity of plasmonic sensors with surface lattice resonance.Nanophotonics (Berlin, Germany) · 2023Article
- Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies.Advanced materials (Deerfield Beach, Fla.) · 2023Review
- Article
- Quantifiable Effect of Interparticle Plasmonic Coupling on Sensitivity and Tuning Range for Wavelength-Mode LSPR Fiber Sensor Fabricated by Simple Immobilization Method.Sensors (Basel, Switzerland) · 2022Article
- Enhanced Label-Free Nanoplasmonic Cytokine Detection in SARS-CoV-2 Induced Inflammation Using Rationally Designed Peptide Aptamer.ACS applied materials & interfaces · 2022Article
- Optimizing Plasmonic Gold Nanorod Deposition on Glass Surfaces for High-Sensitivity Refractometric Biosensing.Nanomaterials (Basel, Switzerland) · 2022Article
- Selective Detection and Ultrasensitive Quantification of SARS-CoV-2 IgG Antibodies in Clinical Plasma Samples Using Epitope-Modified Nanoplasmonic Biosensing Platforms.ACS applied materials & interfaces · 2022Article
- Characterization of Gold Nanorods Conjugated with Synthetic Glycopolymers Using an Analytical Approach Based on spICP-SFMS and EAF4-MALS.Nanomaterials (Basel, Switzerland) · 2021Article
- Computational Optimization of the Size of Gold Nanorods for Single-Molecule Plasmonic Biosensors Operating in Scattering and Absorption Modes.The journal of physical chemistry. C, Nanomaterials and interfaces · 2021Article
- Multiplexed and High-Throughput Label-Free Detection of RNA/Spike Protein/IgG/IgM Biomarkers of SARS-CoV-2 Infection Utilizing Nanoplasmonic Biosensors.Analytical chemistry · 2021Article
- The polymeric glyco-linker controls the signal outputs for plasmonic gold nanorod biosensors due to biocorona formation.Nanoscale · 2021Article
- Localized surface plasmon resonance inflection points for improved detection of chemisorption of 1-alkanethiols under total internal reflection scattering microscopy.Scientific reports · 2021Article
- Recent Advances in Aptamer Sensors.Sensors (Basel, Switzerland) · 2021Review
- Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications.Biosensors · 2020Review
- Optical absorption in array of Ge/Al-shell nanoparticles in an Alumina matrix.Scientific reports · 2020Article
- Shape Effect on the Refractive Index Sensitivity at Localized Surface Plasmon Resonance Inflection Points of Single Gold Nanocubes with Vertices.Scientific reports · 2019Article
- All-Optical Imaging of Gold Nanoparticle Geometry Using Super-Resolution Microscopy.The journal of physical chemistry. C, Nanomaterials and interfaces · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We present the development of an analytical model that can be used for the rational design of a biosensor based on shifts in the local surface plasmon resonance (LSPR) of individual gold nanoparticles. The model relates the peak wavelength of light scattered by an individual plasmonic nanoparticle to the number of bound analyte molecules and provides an analytical formulation that predicts relevant figures-of-merit of the sensor such as the molecular detection limit (MDL) and dynamic range as a function of nanoparticle geometry and detection system parameters. The model calculates LSPR shifts for individual molecules bound by a nanorod, so that the MDL is defined as the smallest number of bound molecules that is measurable by the system, and the dynamic range is defined as the maximum number of molecules that can be detected by a single nanorod. This model is useful because it will allow a priori design of an LSPR sensor with figures-of-merit that can be optimized for the target analyte. This model was used to design an LSPR sensor based on biotin-functionalized gold nanorods that offers the lowest MDL for this class of sensors. The model predicts a MDL of 18 streptavidin molecules for this sensor, which is in good agreement with experiments and estimates. Further, we discuss how the model can be utilized to guide the development of future generations of LSPR biosensors.
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