ArticlePediatric nephrology (Berlin, Germany)2009
Chlorhexidine-based antiseptic solutions effectively reduce catheter-related bacteremia.
Article in Pediatric nephrology (Berlin, Germany), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study.Critical care (London, England) · 2017Trial
- Vascular access for hemodialysis and catheter-related bloodstream infections: a survey on preventive measures and treatment strategies by the EPDWG and ESPN Dialysis Working Group.European journal of pediatrics · 2026Article
- Comparison of Efficacy of 2% Chlorhexidine Gluconate-Alcohol and 10% Povidone-Iodine-Alcohol against Catheter-Related Bloodstream Infections and Bacterial Colonization at Central Venous Catheter Insertion Sites: A Prospective, Single-Center, Open-Label, Crossover Study.Journal of clinical medicine · 2022Article
- Bacterial colonization of non-permanent central venous catheters in hemodialysis dogs.Heliyon · 2020Article
- The Making Dialysis Safer for Patients Coalition: A New Partnership to Prevent Hemodialysis-Related Infections.Clinical journal of the American Society of Nephrology : CJASN · 2018Article
- Hemodialysis Tunneled Catheter-Related Infections.Canadian journal of kidney health and disease · 2016Article
- Infection prevention and the medical director: uncharted territory.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- Vascular access: choice and complications in European paediatric haemodialysis units.Pediatric nephrology (Berlin, Germany) · 2012Article
- Consistency between guidelines and reported practice for reducing the risk of catheter-related infection in British paediatric intensive care units.Intensive care medicine · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this retrospective study was to investigate if the application of chlorhexidine-based solutions (ChloraPrep) to the exit site and the hub of long-term hemodialysis catheters could prevent catheter-related bacteremia (CRB) and prolong catheter survival when compared with povidone-iodine solutions. There were 20,784 catheter days observed. Povidone-iodine solutions (Betadine) were used in the first half of the study and ChloraPrep was used in the second half for all the patients. Both groups received chlorhexidine-impregnated dressings at the exit sites. The use of ChloraPrep significantly decreased the incidence of CRB (1.0 vs 2.2/1,000 catheter days, respectively, P = 0.0415), and hospitalization due to CRB (1.8 days vs 4.1 days/1,000 catheter days, respectively, P = 0.0416). The incidence of exit site infection was similar for the two groups. Both the period of overall catheter survival (207.6 days vs 161.1 days, P = 0.0535) and that of infection-free catheter survival (122.0 days vs 106.9 days, P = 0.1100) tended to be longer for the catheters cleansed with ChloraPrep, with no statistical significance. In conclusion, chlorhexidine-based solutions are more effective for the prevention of CRB than povidone-iodine solutions. This positive impact cannot be explained by decreased number of exit site infections. This study supports the notion that the catheter hub is the entry site for CRB.
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