ArticleCurrent genetics2009
Evolution of carbonic anhydrases in fungi.
Article in Current genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- Fungal Carbonic Anhydrases: A Systematic Review from Molecular Profiling to Pathogenic Regulation inJournal of fungi (Basel, Switzerland) · 2026Review
- Genomic and metagenomic survey of microbial carbonic anhydrase genes reveals novel clades, high diversity, and biome specificity.ISME communications · 2026Article
- Unique evolution of foraminiferal calcification to survive global changes.Science advances · 2023Article
- The vacuolar morphology protein VAC14 plays an important role in sexual development in the filamentous ascomycete Sordaria macrospora.Current genetics · 2022Article
- Contribution of the Mitochondrial Carbonic Anhydrase (MoCA1) to Conidiogenesis and Pathogenesis inFrontiers in microbiology · 2022Article
- A Highlight on the Inhibition of Fungal Carbonic Anhydrases as Drug Targets for the Antifungal Armamentarium.International journal of molecular sciences · 2021Review
- Fungal Carbonyl Sulfide Hydrolase of Trichoderma harzianum Strain THIF08 and Its Relationship with Clade D β-Carbonic Anhydrases.Microbes and environments · 2021Article
- Crystal Structure of β-Carbonic Anhydrase CafA from the Fungal PathogenMolecules and cells · 2020Article
- Anion Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous AscomyceteMetabolites · 2020Article
- Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous AscomyceteMolecules (Basel, Switzerland) · 2020Article
- Soil exchange rates of COS and COThe ISME journal · 2019Article
- The transcription factor PRO44 and the histone chaperone ASF1 regulate distinct aspects of multicellular development in the filamentous fungus Sordaria macrospora.BMC genetics · 2018Article
- COCurrent genetics · 2017Review
- Serum Carbonic Anhydrase 1 is a Biomarker for Diagnosis of HumanThe American journal of tropical medicine and hygiene · 2017Article
- Carbonic Anhydrases in Cnidarians: Novel Perspectives from the Octocorallian Corallium rubrum.PloS one · 2016Article
- Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans.Parasites & vectors · 2014Article
- How protein targeting to primary plastids via the endomembrane system could have evolved? A new hypothesis based on phylogenetic studies.Biology direct · 2013Article
- Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates.BMC biochemistry · 2010Article
- Molecular and biochemical analysis of the beta class carbonic anhydrases in Caenorhabditis elegans.Molecular biology reports · 2010Article
- Biochemistry. CO2mmon sense.Science (New York, N.Y.) · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ubiquitous metalloenzyme carbonic anhydrase (CA) catalyzes the interconversion of carbon dioxide and bicarbonate. This enzyme has been investigated in mammals, plants, algae, bacteria, archaea and fungi. Based on distinct structural characteristics, CAs can be assigned to five independently evolved classes (alpha, beta, gamma, delta and zeta). beta-CAs can be further subdivided into plant-type and cab-type sub-classes. The recent characterization of CAs in fungi led us to initiate a systematic search for these enzymes in filamentous ascomycetes. The genomes of basidiomycetes and hemiascomycetous yeasts contain only beta-CAs, while the filamentous ascomycetes also possess genes encoding alpha-class CAs. Here, we present a phylogenetic analysis of 97 fungal CA sequences that addresses the diversification of fungal CAs. During evolution various gene duplication and gene loss events seem to be the cause for the multiplicity of CAs in filamentous ascomycetes. Our data revealed that during the evolution of filamentous ascomycetes, a gene encoding the plant-type beta-CA was duplicated, resulting in two closely related isoforms, one with and one without an N-terminal mitochondrial target sequence (MTS). The acquisition of the MTS most likely took place after the gene duplication event and after the evolutionary separation of the fungal orders Sordariales and Eurotiales.
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