ArticleNaunyn-Schmiedeberg's archives of pharmacology2009
GABA(A) autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS) in brain?
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Transmitter self-regulation by extracellular glutamate in fresh human cortical slices.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Hypokinesia upon Pallidal Deep Brain Stimulation of Dystonia: Support of a GABAergic Mechanism.Frontiers in neurology · 2013Review
- Modeling effect of GABAergic current in a basal ganglia computational model.Cognitive neurodynamics · 2012Article
- Selective GABA release as a mechanistic basis of high-frequency stimulation used for the treatment of neuropsychiatric diseases.Naunyn-Schmiedeberg's archives of pharmacology · 2011Review
- Effects of antiepileptic drugs on GABA release from rat and human neocortical synaptosomes.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
- Boosting brain excitability by transcranial high frequency stimulation in the ripple range.The Journal of physiology · 2010Article
- An uncommon paraneoplastic Ri-positive opsoclonus-myoclonus-like syndrome and stiff-person syndrome with elevated glutamate/GABA ratio in the cerebrospinal fluid after breast cancer.Journal of neurology · 2010Article
- Effect of High-frequency Electrical Stimulation of Olfactory Bulb on Spontaneous Excitatory Postsynaptic Currents in Hippocampal CA1 Pyramidal Cells of Kindling Rats.Basic and clinical neuroscienceArticle
- Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-frequency stimulation (HFS) in human neocortical slices induces gamma-aminobutyric acid (GABA) release via GABA(A) receptor (GABA(A)R) activation. The mechanism of this effect and the localization of these GABA(A)Rs were now studied. Fresh human neocortical slices were subjected to HFS (130 Hz) in the presence of veratridine (3 microM). As measured by high-performance liquid chromatography, only GABA but not glutamate outflow was affected by HFS/veratridine stimulation. The evoked GABA overflow was abolished by tetrodotoxin and furosemide, suggesting an involvement of action potentials and plasmalemmal chloride gradients. Double immunolabeling showed that GABA(A)Rs are localized on soma and dendrites of GABAergic neurons in the human neocortex. Moreover, in support of a terminal localization of GABA(A)Rs, the K+-evoked [3H]-GABA release from synaptosomes was enhanced by the GABA(A)R agonist muscimol (antagonized by GABA(A)R blockers). We conclude that HFS in human brain neocortex leads to a specific increase of GABA release, which is mediated by facilitatory GABA(A) autoreceptors located on soma, dendrites, and axon terminals of GABAergic neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.