ArticlePloS one2009
Transcriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer's disease.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
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Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Analysis of microRNA and Gene Expression Profiles in Alzheimer's Disease: A Meta-Analysis Approach.Scientific reports · 2018Pooled it
- Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.Molecular neurobiology · 2016Pooled it
- Exploring Gene Expression Patterns in Alzheimer's Disease Using a Human Microarray Data Meta-Analysis.Biology · 2026Article
- Increased GABBR2 Expression on Cell Membranes Causes Increased Ca2 + Inward Flow, Associated with Cognitive Impairment in Early Alzheimer's Disease.Biochemical genetics · 2025Article
- Investigating the Impact of NMDA Receptor Organization and Biological Sex in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.International journal of molecular sciences · 2025Article
- mRNA and circRNA mislocalization to synapses are key features of Alzheimer's disease.PLoS genetics · 2024Article
- Utilities of Isolated Nerve Terminals in Ex Vivo Analyses of Protein Translation in (Patho)physiological Brain States: Focus on Alzheimer's Disease.Molecular neurobiology · 2024Review
- Decanoic Acid Rescues Differences in AMPA-Mediated Calcium Rises in Hippocampal CA1 Astrocytes and Neurons in the 5xFAD Mouse Model of Alzheimer's Disease.Biomolecules · 2023Article
- Reply to: Methodological concerns and lack of evidence for single-synapse RNA-seq.Nature biotechnology · 2023Article
- A beginner's guide into curated analyses of open access datasets for biomarker discovery in neurodegeneration.Scientific data · 2023Article
- Co-expression network analysis of frontal cortex during the progression of Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Revelation of Pivotal Genes Pertinent to Alzheimer's Pathogenesis: A Methodical Evaluation of 32 GEO Datasets.Journal of molecular neuroscience : MN · 2022Article
- Sex Differences in the Behavioral, Molecular, and Structural Effects of Ketamine Treatment in Depression.The international journal of neuropsychopharmacology · 2022Review
- Identification of RNA-RBP Interactions in Subcellular Compartments by CLIP-Seq.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Bioinformatics and system biology approaches to identify pathophysiological impact of COVID-19 to the progression and severity of neurological diseases.Computers in biology and medicine · 2021Article
- Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS.Nature communications · 2021Article
- Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration.Cells · 2021Article
- Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice.Neuroscience · 2021Article
- Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases.Frontiers in cellular neuroscience · 2021Review
- System biology and bioinformatics pipeline to identify comorbidities risk association: Neurodegenerative disorder case study.PloS one · 2021Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
In Alzheimer's disease (AD), early deficits in learning and memory are a consequence of synaptic modification induced by toxic beta-amyloid oligomers (oAbeta). To identify immediate molecular targets downstream of oAbeta binding, we prepared synaptoneurosomes from prefrontal cortex of control and incipient AD (IAD) patients, and isolated mRNAs for comparison of gene expression. This novel approach concentrates synaptic mRNA, thereby increasing the ratio of synaptic to somal mRNA and allowing discrimination of expression changes in synaptically localized genes. In IAD patients, global measures of cognition declined with increasing levels of dimeric Abeta (dAbeta). These patients also showed increased expression of neuroplasticity related genes, many encoding 3'UTR consensus sequences that regulate translation in the synapse. An increase in mRNA encoding the GluR2 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) was paralleled by elevated expression of the corresponding protein in IAD. These results imply a functional impact on synaptic transmission as GluR2, if inserted, maintains the receptors in a low conductance state. Some overexpressed genes may induce early deficits in cognition and others compensatory mechanisms, providing targets for intervention to moderate the response to dAbeta.
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