ReviewNature immunology2009
Navigating the network: signaling cross-talk in hematopoietic cells.
Review in Nature immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Evaluation ofFrontiers in nutrition · 2024Article
- Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Non-monotonic dynamics and crosstalk in signaling pathways and their implications for pharmacology.Scientific reports · 2015Article
- Phosphoproteome profiling of the macrophage response to different toll-like receptor ligands identifies differences in global phosphorylation dynamics.Journal of proteome research · 2014Article
- Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.Nature immunology · 2014Article
- Negative interactions and feedback regulations are required for transient cellular response.Scientific reports · 2014Article
- An Interaction Library for the FcεRI Signaling Network.Frontiers in immunology · 2014Review
- Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.Pharmacology & therapeutics · 2013Review
- Cytokine-induced chromatin modifications of the type I collagen alpha 2 gene during intestinal endothelial-to-mesenchymal transition.Inflammatory bowel diseases · 2013Article
- SignaLink 2 - a signaling pathway resource with multi-layered regulatory networks.BMC systems biology · 2013Article
- Maintaining system homeostasis: the third law of Newtonian immunology.Nature immunology · 2012Article
- Endosomal crosstalk: meeting points for signaling pathways.Trends in cell biology · 2012Article
- Article
- Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Review
- A TIRF microscopy technique for real-time, simultaneous imaging of the TCR and its associated signaling proteins.Journal of visualized experiments : JoVE · 2012Article
- How the TCR balances sensitivity and specificity for the recognition of self and pathogens.Nature immunology · 2012Review
- Charting the NF-κB pathway interactome map.PloS one · 2012Article
- Article
- Network target for screening synergistic drug combinations with application to traditional Chinese medicine.BMC systems biology · 2011Article
- Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum.Science (New York, N.Y.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Recent studies in hematopoietic cells have led to a growing appreciation of the diverse modes of molecular and functional cross-talk between canonical signaling pathways. However, these intersections represent only the tip of the iceberg. Emerging global analytical methods are providing an even richer and more complete picture of the many components that measurably interact in a network manner to produce cellular responses. Here we highlight the pieces in this Focus, emphasize the limitations of the present canonical pathway paradigm, and discuss the value of a systems biology approach using more global, quantitative experimental design and data analysis strategies. Lastly, we urge caution about overly facile interpretation of genome- and proteome-level studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.