ArticleThe Journal of investigative dermatology2009
Distinguishing mouse strains by proteomic analysis of pelage hair.
Article in The Journal of investigative dermatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01841268 (Skin Lipid Profiles in Term and Preterm Infants), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Skin Lipid Profiles in Term and Preterm Infants
Who cites it
19 citing papers in PubMed.
- Proteome of Human Scalp Hair Follicles.Cureus · 2026Article
- Cornified Epithelial Teeth of Jawless Vertebrates Contain Proteins Similar to Keratin-Associated Proteins of Mammalian Skin Appendages.Journal of developmental biology · 2025Article
- Insights from Tandem Mass Tag (TMT) Proteomic Analysis on Protein Network Modification in Control of Yak Hair Follicle Cycle.International journal of molecular sciences · 2025Article
- Environmental pro-oxidants induce altered envelope protein profiles in human keratinocytes.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Trichothiodystrophy hair shafts display distinct ultrastructural features.Experimental dermatology · 2022Article
- Maturation of biomimetic hydroxyapatite in physiological fluids: a physicochemical and proteomic study.Materials today. Bio · 2021Article
- Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases.International journal of molecular sciences · 2020Review
- Corneocyte proteomics: Applications to skin biology and dermatology.Experimental dermatology · 2018Review
- Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains.Analytical chemistry · 2018Article
- Alopecia areata.Nature reviews. Disease primers · 2017Review
- Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening.Methods in molecular biology (Clifton, N.J.) · 2016Article
- The human colostrum whey proteome is altered in gestational diabetes mellitus.Journal of proteome research · 2015Article
- Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis.PeerJ · 2014Article
- Chicken corneocyte cross-linked proteome.Journal of proteome research · 2013Article
- Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics.PloS one · 2012Article
- Localization of hair shaft protein VSIG8 in the hair follicle, nail unit, and oral cavity.The Journal of investigative dermatology · 2011Article
- Proteomic analysis of human nail plate.Journal of proteome research · 2010Article
- Mutations in sterol O-acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice.The Journal of investigative dermatology · 2010Article
- Proteomic analysis of hair shaft and nail plate.Journal of cosmetic scienceArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
AKR/J mice display a hair interior defect (hid) phenotype for which the molecular basis is unknown. To investigate the application of hair-shaft proteomics to the study of such diseases, pelage from AKR/J and two other mouse strains without this defect was analyzed by shotgun proteomics. The results permitted the identification of 111 proteins from tryptic digests of total hair from AKR/J-hid/hid mice, which were predominantly keratins (Krts) and Krt-associated proteins (Krtaps). From the non-solubilizable (crosslinked) fraction of the hair remaining after extensive detergent extraction, 58 proteins were identified. The majority were Krts and Krtaps, but junctional and other membrane proteins, cytoplasmic proteins, and histones were also identified. The results indicate the incorporation of a multitude of proteins into highly crosslinked material. Comparison of unique peptides generated among hair samples from AKR/J-hid/hid, FVB/NJ+/+, and LP/J+/+ mice indicated that these inbred strains could be distinguished by their proteomic patterns. Transmission electron microscopy after mild treatment in detergent and reducing agent permitted the visualization of projections of cortex cells, with characteristic filament patterns, into adjoining medulla cells. Hair shafts from AKR/J mice were deficient in these projections and also exhibited relatively low levels of trichohyalin, a possible contributor to or marker for the hid phenotype.
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Registered trials
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