ArticleGenes and immunity2009
Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex.
Article in Genes and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes locus around TCF19 in the MHC.Human genetics · 2011Pooled it
- Genetic insights into therapeutic targets for gestational diabetes mellitus: a multi-omics analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Article
- Gene expression signature predicts rate of type 1 diabetes progression.EBioMedicine · 2023Article
- NLRC5 promotes transcription ofiScience · 2021Article
- RANKL-Induced Btn2a2 - A T Cell Immunomodulatory Molecule - During Osteoclast Differentiation Fine-Tunes Bone Resorption.Frontiers in endocrinology · 2021Article
- The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes.Frontiers in immunology · 2020Review
- Analysis of macaque BTN3A genes and transcripts in the extended MHC: conserved orthologs of human γδ T cell modulators.Immunogenetics · 2019Article
- Thymus-specific serine protease, a protease that shapes the CD4 T cell repertoire.Immunogenetics · 2019Review
- Butyrophilin3A proteins and Vγ9Vδ2 T cell activation.Seminars in cell & developmental biology · 2018Review
- New Insights Into the Regulation of γδ T Cells by BTN3A and Other BTN/BTNL in Tumor Immunity.Frontiers in immunology · 2018Review
- Evolutionary and polymorphism analyses reveal the central role of BTN3A2 in the concerted evolution of the BTN3 gene family.Immunogenetics · 2017Article
- Immunosurveillance by human γδ T lymphocytes: the emerging role of butyrophilins.F1000Research · 2017Review
- Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.The Journal of experimental medicine · 2016Article
- Immune modulation by butyrophilins.Nature reviews. Immunology · 2014Review
- Sequence of a complete chicken BG haplotype shows dynamic expansion and contraction of two gene lineages with particular expression patterns.PLoS genetics · 2014Article
- Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development.Immunologic research · 2012Review
- Genetics of the HLA region in the prediction of type 1 diabetes.Current diabetes reports · 2011Review
- BLOCK-BASED BAYESIAN EPISTASIS ASSOCIATION MAPPING WITH APPLICATION TO WTCCC TYPE 1 DIABETES DATA.The annals of applied statistics · 2011Article
- Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice.The Journal of clinical investigation · 2011Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
The high-risk human leukocyte antigen (HLA)-DRB1, DQA1 and DQB1 alleles cannot explain the entire type 1 diabetes (T1D) association observed within the extended major histocompatibility complex. We have earlier identified an association with D6S2223, located 2.3 Mb telomeric of HLA-A, on the DRB1(*)03-DQA1(*)0501-DQB1(*)0201 haplotype, and this study aimed to fine-map the associated region also on the DRB1(*)0401-DQA1(*)03-DQB1(*)0302 haplotype, characterized by less extensive linkage disequilibrium. To exclude associations secondary to DRB1-DQA1-DQB1 haplotypes, 205 families with at least one parent homozygous for these loci, were genotyped for 137 polymorphisms. We found novel associations on the DRB1(*)0401-DQA1(*)03-DQB1(*)0302 haplotypic background with eight single nucleotide polymorphisms (SNPs) located within or near the PRSS16 gene. In addition, association at the butyrophilin (BTN)-gene cluster, particularly the BTN3A2 gene, was observed by multilocus analyses. We replicated the associations with SNPs in the PRSS16 region and, albeit weaker, to the BTN3A2 region, in an independent material of 725 families obtained from the Type 1 Diabetes Genetics Consortium. It is important to note that these associations were independent of the HLA-DRB1-DQA1-DQB1 genes, as well as of associations observed at HLA-A, -B and -C. Taken together, our results identify PRSS16 and BTN3A2, two genes thought to play important roles in regulating the immune response, as potentially novel susceptibility genes for T1D.
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