ArticleGenes and immunity2009
Extended IL10 haplotypes and their association with HIV progression to AIDS.
Article in Genes and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- The Enigmatic Interplay of Interleukin-10 in the Synergy of HIV Infection Comorbid with Preeclampsia.International journal of molecular sciences · 2024Review
- Short Communication: Genetic Variation in HumanAIDS research and human retroviruses · 2021Article
- Automated Extraction of Information From Texts of Scientific Publications: Insights Into HIV Treatment Strategies.Frontiers in genetics · 2020Article
- Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro.Cellular & molecular immunology · 2018Article
- Polymorphisms in the IFNγ, IL-10, and TGFβ genes may be associated with HIV-1 infection.Disease markers · 2015Article
- Lack of Association between Interleukin-10 Gene Promoter Polymorphisms with HIV Susceptibility and Progression to AIDS.Iranian journal of pathology · 2015Article
- Effect of MHC haplotype on immune response upon experimental SHIVSF162P4cy infection of Mauritian cynomolgus macaques.PloS one · 2014Article
- Pilot study: possible association of IL10 promoter polymorphisms with CRMO.Rheumatology international · 2012Article
- Association of IL-10-promoter genetic variants with the rate of CD4 T-cell loss, IL-10 plasma levels, and breadth of cytotoxic T-cell lymphocyte response during chronic HIV-1 infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Article
- Influence of cytokines on HIV-specific antibody-dependent cellular cytotoxicity activation profile of natural killer cells.PloS one · 2012Article
- A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia A.Haemophilia : the official journal of the World Federation of Hemophilia · 2011Article
- Mendelian randomization: potential use of genetics to enable causal inferences regarding HIV-associated biomarkers and outcomes.Current opinion in HIV and AIDS · 2010Review
- Interleukin-10 (IL-10) pathway: genetic variants and outcomes of HIV-1 infection in African American adolescents.PloS one · 2010Article
- Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS.The Journal of infectious diseases · 2010Article
- Effect of host genetics on incidence of HIV neuroretinal disorder in patients with AIDS.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Cell type-specific regulation of IL-10 expression in inflammation and disease.Immunologic research · 2010Review
- IL-10 production by CD4+ effector T cells: a mechanism for self-regulation.Mucosal immunology · 2010Review
- The macrophage in HIV-1 infection: from activation to deactivation?Retrovirology · 2010Review
- Immunogenetic influences on acquisition of HIV-1 infection: consensus findings from two African cohorts point to an enhancer element in IL19 (1q32.2).Genes and immunityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
Interleukin-10 (IL-10) is a pleiotropic cytokine with both immunosuppressive and immunostimulatory functions. Its roles in infections and autoimmunity may have resulted in selective pressures on polymorphisms within the gene, leading to genomic coexistence of several semi-conserved haplotypes involved with diverse pathogen interactions during genomic evolution. Previous studies focused either exclusively on promoter haplotypes or on individual SNPs. We genotyped 21 single nucleotide polymorphisms in the human IL10 gene and examined this variation compared to other mammalian species sequences. Haplotype heterogeneity in human populations is centered around 'classic' 'proximal' promoter polymorphisms: -592, -819 and -1082. High-producing GCC haplotypes are by far the most numerous and diverse group, the intermediate IL-10 producing ACC-inclusive haplotypes seem to be related most closely to the ancestral haplotype, and the ATA-inclusive haplotypes cluster a separate branch with strong bootstrap support. We looked at associations of corresponding haplotypes with HIV progression. A haplotype trend regression confirmed that individuals carrying the low-producing ATA-inclusive haplotypes in European Americans progress to AIDS faster, and most likely explain the role of IL10. Our findings are consistent with the hypothesis that existing polymorphisms in this gene may reflect a balance of historic adaptive responses to autoimmune, infectious and other disease agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.