ArticleTransplantation2009
IL10 and IL10 receptor gene variation and outcomes after unrelated and related hematopoietic cell transplantation.
Article in Transplantation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- IL-10 promoter polymorphism associated with decreased risk of aGvHD after stem cell transplantation: a meta-analysis.International journal of hematology · 2013Pooled it
- A novel predictive approach for GVHD after allogeneic SCT based on clinical variables and cytokine gene polymorphisms.Blood advances · 2018Trial
- Sibling donor and recipient immune modulation with atorvastatin for the prophylaxis of acute graft-versus-host disease.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Trial
- Donor Genetic Predisposition to High Interleukin-10 Production Appears Protective against Acute Graft-Versus-Host Disease.International journal of molecular sciences · 2022Article
- Article
- Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease.World journal of gastroenterology · 2017Article
- Article
- Analysis of a Genetic Polymorphism in the Costimulatory Molecule TNFSF4 with Hematopoietic Stem Cell Transplant Outcomes.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2016Article
- Identification and utilization of donor and recipient genetic variants to predict survival after HCT: are we ready for primetime?Current hematologic malignancy reports · 2015Review
- Genomic studies of GVHD-lessons learned thus far.Bone marrow transplantation · 2013Review
- Genetics of graft-versus-host disease: the major histocompatibility complex.Blood reviews · 2013Review
- Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population.Bone marrow transplantation · 2011Article
- Defining genetic risk for graft-versus-host disease and mortality following allogeneic hematopoietic stem cell transplantation.Current opinion in hematology · 2010Review
- Investigation of functional IL-10 gene polymorphism and IL-10 levels in acute graft-versus-host disease.Journal of clinical immunology · 2010Article
- Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies.Critical care (London, England) · 2009Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundResults of a previous study with human leukocyte antigen (HLA)-identical siblings showed individual and synergistic associations of single nucleotide polymorphisms in the promoter region of the recipient's IL10 gene and the donor's IL10 receptor beta (IL-10RB) gene with development of grades III-IV acute graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation.
methodsIn this study of 936 patients who had unrelated donors, genotypes of single nucleotide polymorphisms in the IL10 gene and the IL-10RB gene were evaluated as correlates with outcomes after transplantation.
resultsWe found no statistically significant associations of polymorphisms at positions -3575, -2763, -1082, and -592 of the IL10 gene or codon 238 of the IL10RB gene with severe acute GVHD, extensive chronic GVHD or nonrelapse mortality after hematopoietic cell transplantation. Among HLA-matched unrelated pairs, the patient's IL10/-592 genotype and donor's IL10RB/c238 genotype showed trends suggesting individual and combined associations with grades III-IV acute GVHD similar to those observed among patients with HLA-identical sibling donors.
conclusionsAlthough genetic variation in IL10 pathway affects risk of acute GVHD and non-relapse mortality in HLA-identical sibling transplants, the current results indicate that genetic variation in the IL10 pathway does not significant affect these outcomes in unrelated donor transplants suggesting that the strength of the alloimmune response in the latter exceeds the anti-inflammatory activity of IL10.
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