ArticleTransplantation2009
Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart.
Article in Transplantation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The trial behind it
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Who cites it
60 citing papers in PubMed, 128 citations in OpenAlex.
- Exogenous Signaling Molecules Released from Aptamer-Functionalized Hydrogels Promote the Survival of Mesenchymal Stem Cell Spheroids.ACS applied materials & interfaces · 2020Article
- Ex vivo evaluation of intravitreal mesenchymal stromal cell viability using bioluminescence imaging.Stem cell research & therapy · 2018Article
- Endothelial progenitor cell-conditioned medium promotes angiogenesis and is neuroprotective after spinal cord injury.Neural regeneration research · 2018Article
- Comparing stemness gene expression between stem cell subpopulations from peripheral blood and adipose tissue.American journal of stem cells · 2018Article
- Bioluminescence Assays for Monitoring Chondrogenic Differentiation and Cartilage Regeneration.Sensors (Basel, Switzerland) · 2017Review
- Autophagy mediates the beneficial effect of hypoxic preconditioning on bone marrow mesenchymal stem cells for the therapy of myocardial infarction.Stem cell research & therapy · 2017Article
- Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives.Journal of orthopaedic translation · 2017Review
- Intravenous administration of puppy deciduous teeth stem cells in degenerative valve disease.Veterinary world · 2016Article
- Rebuilding the Damaged Heart: Mesenchymal Stem Cells, Cell-Based Therapy, and Engineered Heart Tissue.Physiological reviews · 2016Review
- Tracking and Quantification of Magnetically Labeled Stem Cells using Magnetic Resonance Imaging.Advanced functional materials · 2016Article
- Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress.International journal of molecular medicine · 2016Article
- Discrepant Results of Experimental Human Mesenchymal Stromal Cell Therapy after Myocardial Infarction: Are Animal Models Robust Enough?PloS one · 2016Article
- Nanoparticles and clinically applicable cell tracking.The British journal of radiology · 2015Review
- Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Staphylococcal Enterotoxin A-Induced Toxic Shock.Infection and immunity · 2015Article
- In vivo therapeutic potential of mesenchymal stromal cells depends on the source and the isolation procedure.Stem cell reports · 2015Article
- Addition of autologous mesenchymal stem cells to whole blood for bioenhanced ACL repair has no benefit in the porcine model.The American journal of sports medicine · 2015Article
- ASC spheroid geometry and culture oxygenation differentially impact induction of preangiogenic behaviors in endothelial cells.Cell transplantation · 2015Article
- Bone marrow-derived mesenchymal stem cells for the treatment of heart failure.Heart failure reviews · 2015Review
- Myogenic differentiation and reparative activity of stromal cells derived from pericardial adipose in comparison to subcutaneous origin.Stem cell research & therapy · 2014Article
- Renin inhibition improves the survival of mesenchymal stromal cells in a mouse model of myocardial infarction.Journal of cardiovascular translational research · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMesenchymal stem cells hold promise for cardiovascular regenerative therapy. Derivation of these cells from the adipose tissue might be easier compared with bone marrow. However, the in vivo fate and function of adipose stromal cells (ASC) in the infarcted heart has never been compared directly to bone marrow-derived mesenchymal cells (MSC).
methodsASC and MSC were isolated from transgenic FVB mice with a beta-actin promoter driving firefly luciferase and green fluorescent protein double fusion reporter gene, and they were characterized using flow cytometry, microscopy, bioluminescence imaging and luminometry. FVB mice (n=8 per group) underwent myocardial infarction followed by intramyocardial injection of 5x10(5) ASC, MSC, fibroblasts (Fibro, positive control), or saline (negative control). Cell survival was measured using bioluminescence imaging for 6 weeks and cardiac function was monitored by echocardiography and pressure-volume analysis. Ventricular morphology was assessed using histology.
resultsASC and MSC were CD34(-), CD45(-), c-Kit(-), CD90(+), Sca-1(+), shared similar morphology and had a population doubling time of approximately 2 days. Cells expressed Fluc reporter genes in a number-dependent fashion as confirmed by luminometry. After cardiac transplantation, both cell types showed drastic donor cell death within 4 to 5 weeks. Furthermore, transplantation of either cell type was not capable of preserving ventricular function and dimensions, as confirmed by pressure-volume-loops and histology.
conclusionThis is the first study comparing the in vivo behavior of both cell types in the infarcted heart. ASC and MSC do not tolerate well in the cardiac environment, resulting in acute donor cell death and a subsequent loss of cardiac function similar to control groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.