ArticleJournal of cell science2009
Distinct role of PLCbeta3 in VEGF-mediated directional migration and vascular sprouting.
Article in Journal of cell science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- Brain endothelial GαEBioMedicine · 2026Article
- Phospholipases: Paving the Way for a New Life.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis.Acta pharmacologica Sinica · 2024Article
- Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis.Immunity · 2023Article
- Advances of medical nanorobots for future cancer treatments.Journal of hematology & oncology · 2023Review
- The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures.Frontiers in oncology · 2023Review
- Bringing a Gene-Activated Bone Substitute Into Clinical Practice: From Bench to Bedside.Frontiers in bioengineering and biotechnology · 2021Article
- Review
- Small GTPases orchestrate cell-cell communication during collective cell movement.Small GTPases · 2020Review
- CD73Journal of extracellular vesicles · 2020Article
- Endothelial CaInternational journal of molecular sciences · 2019Review
- G Protein α Subunit 14 Mediates Fibroblast Growth Factor 2-Induced Cellular Responses in Human Endothelial Cells.Journal of cellular physiology · 2019Article
- GNA11 differentially mediates fibroblast growth factor 2- and vascular endothelial growth factor A-induced cellular responses in human fetoplacental endothelial cells.The Journal of physiology · 2018Article
- Overexpression of preeclampsia induced microRNA-26a-5p leads to proteinuria in zebrafish.Scientific reports · 2018Article
- Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway.Experimental & molecular medicine · 2016Article
- Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Injectable gelatin derivative hydrogels with sustained vascular endothelial growth factor release for induced angiogenesis.Acta biomaterialia · 2015Article
- Expression of phosphoinositide-specific phospholipase C isoforms in native endothelial cells.PloS one · 2015Article
- Ordinary and Activated Bone Grafts: Applied Classification and the Main Features.BioMed research international · 2015Review
- G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Endothelial cell proliferation and migration is essential to angiogenesis. Typically, proliferation and chemotaxis of endothelial cells is driven by growth factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). VEGF activates phospholipases (PLCs) - specifically PLCgamma1 - that are important for tubulogenesis, differentiation and DNA synthesis. However, we show here that VEGF, specifically through VEGFR2, induces phosphorylation of two serine residues on PLCbeta3, and this was confirmed in an ex vivo embryoid body model. Knockdown of PLCbeta3 in HUVEC cells affects IP3 production, actin reorganization, migration and proliferation; whereas migration is inhibited, proliferation is enhanced. Our data suggest that enhanced proliferation is precipitated by an accelerated cell cycle, and decreased migration by an inability to activate CDC42. Given that PLCbeta3 is typically known as an effector of heterotrimeric G-proteins, our data demonstrate a unique crosstalk between the G-protein and receptor tyrosine kinase (RTK) axes and reveal a novel molecular mechanism of VEGF signaling and, thus, angiogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.