ArticleWorld journal of gastroenterology2009
Curcumin suppresses PPARdelta expression and related genes in HT-29 cells.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Exploring 14-3-3ζ: insights into its role in cancer mechanisms and future therapeutic applications.Hereditas · 2026Review
- Delineating the role of nuclear receptors in colorectal cancer, a focused review.Discover oncology · 2024Review
- 14-3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer.Cell communication and signaling : CCS · 2024Review
- Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments.PPAR research · 2022Review
- Curcumin Chemoprevention Reduces the Incidence of Braf Mutant Colorectal Cancer in a Preclinical Study.Digestive diseases and sciences · 2021Article
- Preparation of curcuminoid microemulsions fromRSC advances · 2018Article
- Role of Curcumin in Disease Prevention and Treatment.Advanced biomedical research · 2018Review
- Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ.Molecular and cellular biology · 2013Article
- The effect of curcumin on human bronchial epithelial cells exposed to fine particulate matter: a predictive analysis.Molecules (Basel, Switzerland) · 2012Article
- An important role of interleukin-10 in counteracting excessive immune response in HT-29 cells exposed to Clostridium butyricum.BMC microbiology · 2012Article
- Clostridium butyricum activates TLR2-mediated MyD88-independent signaling pathway in HT-29 cells.Molecular and cellular biochemistry · 2012Article
- Cancer-linked targets modulated by curcumin.International journal of biochemistry and molecular biology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of curcumin on the expression of peroxisome proliferator-activated receptordelta (PPARdelta) and related genes in HT-29 cells.
methodsHT-29 cells were treated with curcumin (0-80 micromol/L) for 24 h. The effects of curcumin on the morphology of HT-29 cells were studied by Hoechst 33342 staining. The activity of caspase-3 was determined using DEVD-pNA as substrate. The levels of peroxisome PPARdelta, 14-3-3epsilon and vascular endothelial growth factor (VEGF) in HT-29 cells were determined by Western blotting analysis and their mRNA expression was determined by real-time quantitative RT-PCR.
resultsTreatment with 10-80 micromol/L curcumin induced typical features of apoptosis and activated the caspase-3 in HT-29 cells. The expression of PPARdelta, 14-3-3epsilon and VEGF was reduced and the activity of beta-catenin/Tcf-4 signaling was inhibited by curcumin treatment.
conclusionCurcumin can induce apoptosis of HT-29 cells and down-regulate the expression of PPARdelta, 14-3-3epsilon and VEGF in HT-29.
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