ArticleProteomics2009
Subproteome analysis of the neutrophil cytoskeleton.
Article in Proteomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Identification of telomere-related diagnostic markers in osteoarthritis based on bioinformatics analysis and machine learning.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025Article
- Article
- A Precision Medicine Approach Uncovers a Unique Signature of Neutrophils in Patients With Brushite Kidney Stones.Kidney international reports · 2020Article
- Cytonemes Versus Neutrophil Extracellular Traps in the Fight of Neutrophils with Microbes.International journal of molecular sciences · 2020Review
- Review
- IL8 and PMA Trigger the Regulation of Different Biological Processes in Granulocyte Activation.Frontiers in immunology · 2019Article
- Transketolase and vitamin B1 influence on ROS-dependent neutrophil extracellular traps (NETs) formation.PloS one · 2019Article
- Expression and regulation of drug transporters in vertebrate neutrophils.Scientific reports · 2017Article
- Fluid phase recognition molecules in neutrophil-dependent immune responses.Seminars in immunology · 2016Review
- Challenges and Strategies for Proteome Analysis of the Interaction of Human Pathogenic Fungi with Host Immune Cells.Proteomes · 2015Review
- Procedures for the biochemical enrichment and proteomic analysis of the cytoskeletome.Analytical biochemistry · 2014Article
- Technical note: proteomic approaches to fundamental questions about neutrophil biology.Journal of leukocyte biology · 2013Review
- Trauma-associated human neutrophil alterations revealed by comparative proteomics profiling.Proteomics. Clinical applications · 2013Article
- Proteomic and biochemical methods to study the cytoskeletome.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Susceptibility to leprosy is associated with M-ficolin polymorphisms.Journal of clinical immunology · 2013Article
- Proteomic approaches to understanding the role of the cytoskeleton in host-defense mechanisms.Expert review of proteomics · 2011Review
- Proteomic and metabolomic profiles in atherothrombotic vascular disease.Current atherosclerosis reports · 2010Review
- Application of proteomics to neutrophil biology.Journal of proteomics · 2010Review
- Quantitative organelle proteomics of MCF-7 breast cancer cells reveals multiple subcellular locations for proteins in cellular functional processes.Journal of proteome research · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Neutrophils play a key role in the early host-defense mechanisms due to their capacity to migrate into inflamed tissues and phagocytose microorganisms. The cytoskeleton has an essential role in these neutrophil functions, however, its composition is still poorly understood. We separately analyzed different cytoskeletal compartments: cytosolic skeleton, phagosome membrane skeleton, and plasma membrane skeleton. Using a proteomic approach, 138 nonredundant proteins were identified. Proteins not previously known to associate with the skeleton were: n-acetylglucosamine kinase, phosphoglycerate mutase 1, prohibitin, ficolin-1, phosphogluconate dehydrogenase, glucosidase, transketolase, major vault protein, valosin-containing protein, aldehyde dehydrogenase, and lung cancer-related protein-8 (LCRP8). The majority of these proteins can be classified as energy metabolism enzymes. Such a finding was interesting because neutrophil energy metabolism is unusual, mainly relying on glycolysis. The enrichment of phosphoglycerate mutase in cytosolic skeleton was additionally indicated by the use of Western blotting. This is the broadest subcellular investigation to date of the neutrophil cytoskeletal proteome and the first proteomic analysis in any cell type of the phagosome skeleton. The association of metabolic enzymes with cytoskeleton is suggestive of the importance of their localized enrichment and macromolecular organization in neutrophils.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.