ArticleHippocampus2010
Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy.
Article in Hippocampus, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 61 citations in OpenAlex.
- Acute hyperexcitability differentially affects hippocampal neurogenesis features and spatial memory.Frontiers in cellular neuroscience · 2026Article
- Sex-based differences in the long-term fate of hippocampal neurons born after a traumatic brain injury.Frontiers in behavioral neuroscience · 2025Article
- Interplay of epilepsy and long-term potentiation: implications for memory.Frontiers in neuroscience · 2024Review
- Hippocampal glucocorticoid receptors modulate status epilepticus severity.Neurobiology of disease · 2023Article
- Article
- Impact of Raptor and Rictor Deletion on Hippocampal Pathology Following Status Epilepticus.Journal of molecular neuroscience : MN · 2022Article
- Convulsive behaviors of spontaneous recurrent seizures in a mouse model of extended hippocampal kindling.Frontiers in behavioral neuroscience · 2022Article
- The glucocorticoid receptor specific modulator CORT108297 reduces brain pathology following status epilepticus.Experimental neurology · 2021Article
- Silencing miR-20a-5p inhibits axonal growth and neuronal branching and prevents epileptogenesis through RGMa-RhoA-mediated synaptic plasticity.Journal of cellular and molecular medicine · 2020Article
- LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling.Journal of neurophysiology · 2019Article
- Experience-Dependent Structural Plasticity of Adult-Born Neurons in the Aging Hippocampus.Frontiers in neuroscience · 2019Article
- Glutamate Imaging Reveals Multiple Sites of Stochastic Release in the CA3 Giant Mossy Fiber Boutons.Frontiers in cellular neuroscience · 2019Article
- Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection.Molecular aspects of medicine · 2018Review
- RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy.Molecular neurobiology · 2018Article
- Contributions of Adult-Generated Granule Cells to Hippocampal Pathology in Temporal Lobe Epilepsy: A Neuronal Bestiary.Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Signaling Pathways and Cellular Mechanisms Regulating Mossy Fiber Sprouting in the Development of Epilepsy.Frontiers in neurology · 2018Review
- Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice.IBRO reports · 2017Article
- Closing the gap: long-term presynaptic plasticity in brain function and disease.Current opinion in neurobiology · 2017Review
- Short-Term Depression of Sprouted Mossy Fiber Synapses from Adult-Born Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Disrupted hippocampal network physiology following PTEN deletion from newborn dentate granule cells.Neurobiology of disease · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Altered granule cell>>CA3 pyramidal cell synaptic connectivity may contribute to the development of limbic epilepsy. To explore this possibility, granule cell giant mossy fiber bouton plasticity was examined in the kindling and pilocarpine models of epilepsy using green fluorescent protein-expressing transgenic mice. These studies revealed significant increases in the frequency of giant boutons with satellite boutons 2 days and 1 month after pilocarpine status epilepticus, and increases in giant bouton area at 1 month. Similar increases in giant bouton area were observed shortly after kindling. Finally, both models exhibited plasticity of mossy fiber giant bouton filopodia, which contact GABAergic interneurons mediating feedforward inhibition of CA3 pyramids. In the kindling model, however, all changes were fleeting, having resolved by 1 month after the last evoked seizure. Together, these findings demonstrate striking structural plasticity of granule cell mossy fiber synaptic terminal structure in two distinct models of adult limbic epileptogenesis. We suggest that these plasticities modify local connectivities between individual mossy fiber terminals and their targets, inhibitory interneurons, and CA3 pyramidal cells potentially altering the balance of excitation and inhibition during the development of epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.