ArticleJournal of molecular evolution2009
Tentacles of venom: toxic protein convergence in the Kingdom Animalia.
Article in Journal of molecular evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 71 citations in OpenAlex.
- Tissue-Specific Gene Expression of Digestive Tract Glands inAnimals : an open access journal from MDPI · 2025Article
- Comprehensive analysis of the global impact and distribution of tick paralysis, a deadly neurological yet fully reversible condition.Clinical microbiology reviews · 2024Review
- Parasitization ofInsects · 2023Article
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- Bioactive Peptides and Proteins from Wasp Venoms.Biomolecules · 2022Review
- Adaptive venom evolution and toxicity in octopods is driven by extensive novel gene formation, expansion, and loss.GigaScience · 2020Article
- Putative Antimicrobial Peptides of the Posterior Salivary Glands from the CephalopodAntibiotics (Basel, Switzerland) · 2020Article
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- A Recurrent Motif: Diversity and Evolution of ShKT Domain Containing Proteins in the Vampire SnailToxins · 2019Article
- Article
- Tick Paralysis: Solving an Enigma.Veterinary sciences · 2018Review
- Are Fireworms Venomous? Evidence for the Convergent Evolution of Toxin Homologs in Three Species of Fireworms (Annelida, Amphinomidae).Genome biology and evolution · 2018Article
- Venomics of Remipede Crustaceans Reveals Novel Peptide Diversity and Illuminates the Venom's Biological Role.Toxins · 2017Article
- Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system.BMC evolutionary biology · 2017Article
- Salivary Glands in Predatory Mollusks: Evolutionary Considerations.Frontiers in physiology · 2017Review
- Article
- Differential Properties of Venom Peptides and Proteins in Solitary vs. Social Hunting Wasps.Toxins · 2016Review
- Chemical Tools of Octopus maya during Crab Predation Are Also Active on Conspecifics.PloS one · 2016Article
- The Rise and Fall of an Evolutionary Innovation: Contrasting Strategies of Venom Evolution in Ancient and Young Animals.PLoS genetics · 2015Article
- Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The origin and evolution of venom in many animal orders remain controversial or almost entirely uninvestigated. Here we use cDNA studies of cephalopod posterior and anterior glands to reveal a single early origin of the associated secreted proteins. Protein types recovered were CAP (CRISP, Antigen 5 [Ag5] and Pathogenesis-related [PR-1]), chitinase, peptidase S1, PLA(2) (phospholipase A(2)), and six novel peptide types. CAP, chitinase, and PLA(2) were each recovered from a single species (Hapalochlaena maculosa, Octopus kaurna, and Sepia latimanus, respectively), while peptidase S1 transcripts were found in large numbers in all three posterior gland libraries. In addition, peptidase S1 transcripts were recovered from the anterior gland of H. maculata. We compare their molecular evolution to that of related proteins found in invertebrate and vertebrate venoms, revealing striking similarities in the types of proteins selected for toxic mutation and thus shedding light on what makes a protein amenable for use as a toxin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.