ArticleEuropean journal of clinical pharmacology2009
Regional surveillance of emergency-department visits for outpatient adverse drug events.
Article in European journal of clinical pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Effectiveness and safety of beta blockers in the management of hypertension in older adults: a systematic review to help reduce inappropriate prescribing.BMC geriatrics · 2017Pooled it
- Estimating cost savings from reducing antibiotic overprescription in european general practices.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Article
- Development and Validation of a Trigger Tool for Identifying Drug-Related Emergency Department Visits.International journal of environmental research and public health · 2021Article
- Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department.European journal of clinical pharmacology · 2021Article
- Italian Emergency Department Visits and Hospitalizations for Outpatients' Adverse Drug Events: 12-Year Active Pharmacovigilance Surveillance (The MEREAFaPS Study).Frontiers in pharmacology · 2020Article
- Characterization and preventability of adverse drug events as cause of emergency department visits: a prospective 1-year observational study.BMC pharmacology & toxicology · 2019Observational
- Understanding adverse drug-related emergency department visits: development of a conceptual model through a systematic review.Therapeutic advances in drug safety · 2019Review
- Medication-related visits in a pediatric emergency department: an 8-years retrospective analysis.Italian journal of pediatrics · 2017Article
- Indications of newer and older anti-epileptic drug use: findings from a southern Italian general practice setting from 2005-2011.British journal of clinical pharmacology · 2015Article
- Epidemiology of adverse drug reactions in Europe: a review of recent observational studies.Drug safety · 2015Review
- Patterns of Adverse Drug Reactions in Different Age Groups: Analysis of Spontaneous Reports by Community Pharmacists.PloS one · 2015Article
- Adverse drug reactions in an emergency medical dispatching centre.European journal of clinical pharmacology · 2014Observational
- Application of the Pareto principle to identify and address drug-therapy safety issues.European journal of clinical pharmacology · 2014Article
- Predictors of mortality in atypical antipsychotic-treated community-dwelling elderly patients with behavioural and psychological symptoms of dementia: a prospective population-based cohort study from Italy.European journal of clinical pharmacology · 2014Article
- Seriousness, preventability, and burden impact of reported adverse drug reactions in Lombardy emergency departments: a retrospective 2-year characterization.ClinicoEconomics and outcomes research : CEOR · 2014Article
- Article
- Pharmacovigilance in Italy: An overview.Journal of pharmacology & pharmacotherapeutics · 2013Review
- Hypoglycemia, polycythemia and hyponatremia in a newborn exposed to nebivolol during pregnancy.Journal of pharmacology & pharmacotherapeuticsArticle
- Complete resistance after maximal dose of rocuronium.Journal of pharmacology & pharmacotherapeuticsArticle
- Prevalence of Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia.Drugs - real world outcomesArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the (1) incidence of adverse drug events (ADEs) in 10 emergency department (EDs) of general hospitals in the Regione Campania (southern Italy), (2) rate of ADE-related hospital admissions, (3) drug classes most frequently involved, and (4) the types of ADEs and their frequency.
methodsWe performed a cohort study of all patients attending the EDs. This study was carried out in two observational periods of 10 days each in 10 EDs. Demographic, clinical, and pharmacological data about all patients admitted to EDs were collected by trained and qualified monitors. Records related to ADEs were analyzed and validated by a specific scientific committee.
resultsOf 7,861 ED visits, 96 were ADE-related. The incidence of hospitalization was higher in patients who had taken medication than in patients with a negative drug history (24.9 vs. 16.4%). ADEs were significantly more frequent in women. Patients aged between 60 and 69 years and between 30 and 39 years were significantly more likely to experience an ADE. Serious ADEs were identified in 20 ED visits (20.8% of total sample). Antibiotics, NSAIDs, and agents acting on the renin-angiotensin system were the drugs most often involved in ADEs. In multivariate analyses, the adjusted odds ratio was 3.4 (95% CI: 1.07-2.84) for patients taking NSAIDs, 4.78 (95% CI: 2.26-10.12) for those taking beta(2)-adrenergic-receptor agonists, and 6.20 (95%CI: 2.74-14.06) for those taking beta-lactam antibiotics.
conclusionThis study shows that ADEs are an important problem in industrialized countries. Moreover, it shows that ADEs affect hospital admission rates and reinforces the importance of drug-induced disease as a public health problem.
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