ArticleMolecular systems biology2009
Force- and length-dependent catastrophe activities explain interphase microtubule organization in fission yeast.
Article in Molecular systems biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation.Nature communications · 2026Article
- Microtubule polymerization generates microtentacles important in circulating tumor cell invasion.Biophysical journal · 2025Article
- Microtubule competition and cell growth recenter the nucleus after anaphase in fission yeast.Molecular biology of the cell · 2023Article
- Reliable and robust control of nucleus centering is contingent on nonequilibrium force patterns.iScience · 2023Article
- Article
- Ends and middle: Global force balance and septum location in fission yeast.The European physical journal. E, Soft matter · 2020Article
- Nuclear Mechanics in the Fission Yeast.Cells · 2019Review
- Augmin accumulation on long-lived microtubules drives amplification and kinetochore-directed growth.The Journal of cell biology · 2019Article
- Search and Capture Efficiency of Dynamic Microtubules for Centrosome Relocation during IS Formation.Biophysical journal · 2019Article
- Microtubule stabilization drives 3D centrosome migration to initiate primary ciliogenesis.The Journal of cell biology · 2017Article
- Mechanism of nuclear movements in a multinucleated cell.Molecular biology of the cell · 2017Article
- A Motor-Gradient and Clustering Model of the Centripetal Motility of MTOCs in Meiosis I of Mouse Oocytes.PLoS computational biology · 2016Article
- Contribution of actin filaments and microtubules to cell elongation and alignment depends on the grating depth of microgratings.Journal of nanobiotechnology · 2016Article
- Chimera proteins with affinity for membranes and microtubule tips polarize in the membrane of fission yeast cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A comprehensive model to predict mitotic division in budding yeasts.Molecular biology of the cell · 2015Article
- Fission yeast kinesin-8 controls chromosome congression independently of oscillations.Journal of cell science · 2015Article
- Geometrical and mechanical properties control actin filament organization.PLoS computational biology · 2015Article
- Article
- Budding yeast kinetochore proteins, Chl4 and Ctf19, are required to maintain SPB-centromere proximity during G1 and late anaphase.PloS one · 2014Article
- The cell-end marker TeaA and the microtubule polymerase AlpA contribute to microtubule guidance at the hyphal tip cortex of Aspergillus nidulans to provide polarity maintenance.Journal of cell science · 2013Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The cytoskeleton is essential for the maintenance of cell morphology in eukaryotes. In fission yeast, for example, polarized growth sites are organized by actin, whereas microtubules (MTs) acting upstream control where growth occurs. Growth is limited to the cell poles when MTs undergo catastrophes there and not elsewhere on the cortex. Here, we report that the modulation of MT dynamics by forces as observed in vitro can quantitatively explain the localization of MT catastrophes in Schizosaccharomyces pombe. However, we found that it is necessary to add length-dependent catastrophe rates to make the model fully consistent with other previously measured traits of MTs. We explain the measured statistical distribution of MT-cortex contact times and re-examine the curling behavior of MTs in unbranched straight tea1Delta cells. Importantly, the model demonstrates that MTs together with associated proteins such as depolymerizing kinesins are, in principle, sufficient to mark the cell poles.
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