ReviewNephron. Experimental nephrology2009
The pathogenic role of Notch activation in podocytes.
Review in Nephron. Experimental nephrology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 55 citations in OpenAlex.
- Calycosin ameliorates albuminuria in nephrotic syndrome by targeting Notch1/Snail pathway.BMC nephrology · 2025Article
- Liraglutide Ameliorates Renal Endothelial Dysfunction in Diabetic Rats Through the Inhibition of the Dll4/Notch2 Pathway.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- The AKI-to-CKD Transition: The Role of Uremic Toxins.International journal of molecular sciences · 2023Review
- Molecular pathways that drive diabetic kidney disease.The Journal of clinical investigation · 2023Review
- ADAMs family in kidney physiology and pathology.EBioMedicine · 2021Review
- Sirtuins and Renal Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021Review
- The Effect of Interleukin-4 and Dexamethasone on RNA-Seq-Based Transcriptomic Profiling of Human Podocytes: A Potential Role in Minimal Change Nephrotic Syndrome.Journal of clinical medicine · 2021Article
- Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria.BMJ open diabetes research & care · 2020Article
- Notch inhibitor mitigates renal ischemia‑reperfusion injury in diabetic rats.Molecular medicine reports · 2020Article
- VEGFR2 Blockade Improves Renal Damage in an Experimental Model of Type 2 Diabetic Nephropathy.Journal of clinical medicine · 2020Article
- Notch Signaling in Kidney Development, Maintenance, and Disease.Biomolecules · 2019Review
- Growth hormone induces Notch1 signaling in podocytes and contributes to proteinuria in diabetic nephropathy.The Journal of biological chemistry · 2019Article
- Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling.Journal of cellular and molecular medicine · 2017Article
- The role of Notch signaling in kidney podocytes.Clinical and experimental nephrology · 2017Review
- Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog.Nature reviews. Nephrology · 2016Review
- Combined blockade of angiotensin II and prorenin receptors ameliorates podocytic apoptosis induced by IgA-activated mesangial cells.Apoptosis : an international journal on programmed cell death · 2015Article
- Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes.Mediators of inflammation · 2015Review
- Kick it up a notch: Notch signaling and kidney fibrosis.Kidney international supplements · 2014Review
- A multicolor podocyte reporter highlights heterogeneous podocyte changes in focal segmental glomerulosclerosis.Kidney international · 2014Article
- Adult-onset renal failure in a family with Alagille syndrome with proteinuria and a novel JAG1 mutation.Clinical kidney journal · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Podocytes play a key role in the maintenance of the glomerular filtration barrier. Depletion or dysregulative mechanisms of podocytes can lead to the development of glomerulosclerosis. Signaling pathways that control these processes in podocytes are not fully understood. Recent studies from our and other laboratories found that genes that belong to the Notch pathway are regulated in patients and in animal models of renal disease. Genetic studies performed on mice with conditional expression of active Notch1 protein showed massive albuminuria, glomerulosclerosis, and ultimately renal failure and death of the animals. gamma-Secretase inhibitors and genetic deletion of Notch transcriptional binding partner (Rbpj) protected animals from nephrotic syndrome. Further studies are needed to define whether the activation of Notch pathway in podocytes represents a common pathomechanism in glomerular injury, and its potential to be a therapeutic target for the treatment of chronic kidney disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.