Trial reportCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2009
Prenatal X-ray exposure and rhabdomyosarcoma in children: a report from the children's oncology group.
Trial report in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- The Capacity of Drug-Metabolising Enzymes in Modulating the Therapeutic Efficacy of Drugs to Treat Rhabdomyosarcoma.Cancers · 2024Review
- Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies.Cancers · 2023Review
- Rhabdomyosarcoma in children: Retrospective analysis from a single tertiary care center in Saudi Arabia.Cancer reports (Hoboken, N.J.) · 2023Article
- Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis.Open medicine (Warsaw, Poland) · 2023Review
- Epithelioid Type Tongue Rhabdomyosarcoma in a Pediatric Patient: A Case Report With Literature Review.Cureus · 2022Article
- Cancer risks among studies of medical diagnostic radiation exposure in early life without quantitative estimates of dose.The Science of the total environment · 2022Review
- Diagnostic Imaging of Pregnant Women and Fetuses: Literature Review.Bioengineering (Basel, Switzerland) · 2022Review
- Pediatric Rhabdomyosarcoma: Epidemiology and Genetic Susceptibility.Journal of clinical medicine · 2021Review
- Rhabdomyosarcoma.Nature reviews. Disease primers · 2019Review
- The Role of Childhood Infections and Immunizations on Childhood Rhabdomyosarcoma: A Report From the Children's Oncology Group.Pediatric blood & cancer · 2016Article
- Rhabdomyosarcoma in adults: new perspectives on therapy.Current treatment options in oncology · 2015Review
- Family history of cancer and childhood rhabdomyosarcoma: a report from the Children's Oncology Group and the Utah Population Database.Cancer medicine · 2015Article
- Parental military service, agent orange exposure, and the risk of rhabdomyosarcoma in offspring.The Journal of pediatrics · 2014Article
- Maternal and birth characteristics and childhood rhabdomyosarcoma: a report from the Children's Oncology Group.Cancer causes & control : CCC · 2014Article
- Allergies, atopy, immune-related factors and childhood rhabdomyosarcoma: a report from the Children's Oncology Group.International journal of cancer · 2014Article
- X-ray radiation and the risk of multiple sclerosis: Do the site and dose of exposure matter?Medical journal of the Islamic Republic of Iran · 2014Article
- Early life factors and risk of childhood rhabdomyosarcoma.Frontiers in public health · 2013Article
- Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma.Cancer genetics · 2012Article
- Childhood rhabdomyosarcoma: new insight on biology and treatment.Current oncology reports · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
The association between antenatal diagnostic X-ray exposure and risk of rhabdomyosarcoma in children was assessed in a national case-control study of 319 rhabdomyosarcoma cases and 319 matched controls. Data were collected by telephone interviews of subjects' parents. Overall, an odds ratio (OR) of 1.9 [95% confidence interval (CI), 1.1-3.4] was found for any X-ray examination of the mother during pregnancy. Risk was greatest for X-ray exposure during the first trimester (OR, 5.7; 95% CI, 1.2-27.8) and was also increased for the third trimester (OR, 2.0; 95% CI, 0.9-4.6), whereas second trimester exposure was not associated with increased risk. A nonsignificant increase in risk was found for any X-rays of the abdomen, pelvis, chest, or back. Increased risk was significantly associated with "other" X-ray exposures (relative risk, 2.9; 95% CI, 1.1-7.7), primarily composed of dental X-rays. The association was strongest between embryonal rhabdomyosarcoma and first trimester exposure (relative risk, 10.5; 95% CI, 1.5-458.4). This observation regarding embryonal rhabdomyosarcoma, and our previous report of an increased frequency of major malformations in rhabdomyosarcoma are compatible with findings from animal studies in which Ptc heterozygous knockout mice exhibited an increased risk of radiation-induced development defects and of spontaneously occurring embryonal rhabdomyosarcoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.