ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2009
Cardiorespiratory fitness and digestive cancer mortality: findings from the aerobics center longitudinal study.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Physical activity interventions for disease-related physical and mental health during and following treatment in people with non-advanced colorectal cancer.The Cochrane database of systematic reviews · 2020Pooled it
- Physical Activity and the Risk of Liver Cancer: A Systematic Review and Meta-Analysis of Prospective Studies and a Bias Analysis.Journal of the National Cancer Institute · 2019Pooled it
- Physical Activity and the Biliary Tract in Health and Disease.Sports medicine (Auckland, N.Z.) · 2015Pooled it
- The effect of different telerehabilitation technologies on the management of cardiovascular disease in oncology survivors: systematic review.Journal of cancer survivorship : research and practice · 2025Review
- Change in Cardiorespiratory Fitness and the Risk of Colorectal and Prostate Cancer Incidence in Men.Cancer medicine · 2024Article
- Quality of Life of Colorectal Cancer Patients: A Literary Review.Iranian journal of public health · 2024Review
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- Rehabilitation strategies following oesophagogastric and Hepatopancreaticobiliary cancer (ReStOre II): a protocol for a randomized controlled trial.BMC cancer · 2020Article
- Cardiorespiratory fitness and adiposity in breast cancer survivors: is meeting current physical activity recommendations really enough?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
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- Cardiorespiratory fitness and risk of site-specific cancers: a long-term prospective cohort study.Cancer medicine · 2017Article
- Recent advances in the link between physical activity, sedentary behavior, physical fitness, and colorectal cancer.F1000Research · 2017Review
- Association of Physical Activity by Type and Intensity With Digestive System Cancer Risk.JAMA oncology · 2016Article
- Measured cardiorespiratory fitness and self-reported physical activity: associations with cancer risk and death in a long-term prospective cohort study.Cancer medicine · 2016Article
- Physical inactivity and low fitness deserve more attention to alter cancer risk and prognosis.Cancer prevention research (Philadelphia, Pa.) · 2015Review
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- Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men.BMC public health · 2014Article
- Chronic weight dissatisfaction predicts type 2 diabetes risk: aerobic center longitudinal study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2014Article
- Cancer prevention among adults aged 45-64 years: setting the stage.American journal of preventive medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Although higher levels of physical activity are inversely associated with risk of colon cancer, few prospective studies have evaluated overall digestive system cancer mortality in relation to cardiorespiratory fitness (CRF). The authors examined this association among 38,801 men ages 20 to 88 years who performed a maximal treadmill exercise test at baseline in the Aerobics Center Longitudinal Study (Dallas, TX) during 1974 to 2003. Mortality was assessed over 29 years of follow-up (1974-2003). Two hundred eighty-three digestive system cancer deaths occurred during a mean 17 years of observation. Age-adjusted mortality rates per 10,000 person-years according to low, moderate, and high CRF groups were 6.8, 4.0, and 3.3 for digestive system cancer (P(trend) < 0.001). After adjustment for age, examination year, body mass index, smoking, drinking, family history of cancer, personal history of diabetes, hazard ratios (95% confidence intervals) for overall digestive cancer deaths for those in the middle and upper 40% of the distribution of CRF relative to those in the lowest 20% were 0.66 (0.49-0.88) and 0.56 (0.40-0.80), respectively. Being fit (the upper 80% of CRF) was associated with a lower risk of mortality from colon [0.61 (0.37-1.00)], colorectal [0.58 (0.37-0.92)], and liver cancer [0.28 (0.11-0.72)] compared with being unfit (the lowest 20% of CRF). These findings support a protective role of CRF against total digestive tract, colorectal, and liver cancer deaths in men.
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