ArticleBMC infectious diseases2009
Causative agent distribution and antibiotic therapy assessment among adult patients with community acquired pneumonia in Chinese urban population.
Article in BMC infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Diagnosis of mycoplasma pneumoniae by loop-mediated isothermal amplification: systematic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- The bacterial aetiology of adult community-acquired pneumonia in Asia: a systematic review.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2014Pooled it
- Atypical pneumonia (Review).Experimental and therapeutic medicine · 2024Review
- Identification ofThe Journal of international medical research · 2022Article
- Genotypic and Phenotypic Characteristics ofPathogens (Basel, Switzerland) · 2022Article
- Efficacy and Safety of Ceftaroline Fosamil in Hospitalized Patients with Community-Acquired Pneumonia in China: Subset Analysis of an International Phase 3 Randomized Controlled Trial.Infection and drug resistance · 2022Article
- Incidence and disease burden of community-acquired pneumonia in southeastern China: data from integrated medical resources.Human vaccines & immunotherapeutics · 2021Article
- Incidence, Etiology, and Environmental Risk Factors of Community-Acquired Pneumonia Requiring Hospitalization in China: A 3-Year, Prospective, Age-Stratified, Multicenter Case-Control Study.Open forum infectious diseases · 2021Article
- Analysis of antibiotic usage for viral community-acquired pneumonia in adults.Frontiers of medicine · 2021Article
- Antibodies against atypical pathogens and respiratory viruses detected by Pneumoslide IgM test in adults with community-acquired pneumonia in Guangzhou City.Journal of clinical laboratory analysis · 2020Article
- Review
- Distribution of the atypical pathogens of community-acquired pneumonia to disease severity.Journal of thoracic disease · 2018Article
- Diagnosis and treatment of community-acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese Thoracic Society, Chinese Medical Association.The clinical respiratory journal · 2018Review
- Contemporary Situation of Community-acquired Pneumonia in China: A Systematic Review.Journal of translational internal medicine · 2018Article
- A retrospective seroepidemiologic survey of Chlamydia pneumoniae infection in patients in Beijing between 2008 and 2017.PloS one · 2018Article
- Community-Acquired Pneumonia in the Asia-Pacific Region.Seminars in respiratory and critical care medicine · 2016Review
- A randomized, open, multicenter clinical study on the short course of intravenous infusion of 750 mg of levofloxacin and the sequential standard course of intravenous infusion/oral administration of 500 mg of levofloxacin for treatment of community-acquired pneumonia.Journal of thoracic disease · 2016Article
- Different microbiological and clinical aspects of lower respiratory tract infections between China and European/American countries.Journal of thoracic disease · 2014Article
- Review
- Accuracy of IgM antibody testing, FQ-PCR and culture in laboratory diagnosis of acute infection by Mycoplasma pneumoniae in adults and adolescents with community-acquired pneumonia.BMC infectious diseases · 2013Article
Corrections and comments
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Authors and funding
26 authors at 14 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKnowledge of predominant microbial patterns in community-acquired pneumonia (CAP) constitutes the basis for initial decisions about empirical antimicrobial treatment, so a prospective study was performed during 2003-2004 among CAP of adult Chinese urban populations.
methodsQualified patients were enrolled and screened for bacterial, atypical, and viral pathogens by sputum and/or blood culturing, and by antibody seroconversion test. Antibiotic treatment and patient outcome were also assessed.
resultsNon-viral pathogens were found in 324/610 (53.1%) patients among whom M. pneumoniae was the most prevalent (126/610, 20.7%). Atypical pathogens were identified in 62/195 (31.8%) patients carrying bacterial pathogens. Respiratory viruses were identified in 35 (19%) of 184 randomly selected patients with adenovirus being the most common (16/184, 8.7%). The nonsusceptibility of S. pneumoniae to penicillin and azithromycin was 22.2% (Resistance (R): 3.2%, Intermediate (I): 19.0%) and 79.4% (R: 79.4%, I: 0%), respectively. Of patients (312) from whom causative pathogens were identified and antibiotic treatments were recorded, clinical cure rate with beta-lactam antibiotics alone and with combination of a beta-lactam plus a macrolide or with fluoroquinolones was 63.7% (79/124) and 67%(126/188), respectively. For patients having mixed M. pneumoniae and/or C. pneumoniae infections, a better cure rate was observed with regimens that are active against atypical pathogens (e.g. a beta-lactam plus a macrolide, or a fluoroquinolone) than with beta-lactam alone (75.8% vs. 42.9%, p = 0.045).
conclusionIn Chinese adult CAP patients, M. pneumoniae was the most prevalent with mixed infections containing atypical pathogens being frequently observed. With S. pneumoniae, the prevalence of macrolide resistance was high and penicillin resistance low compared with data reported in other regions.
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