ArticleCell motility and the cytoskeleton2009
Kinesin-5 in Drosophila embryo mitosis: sliding filament or spindle matrix mechanism?
Article in Cell motility and the cytoskeleton, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- P23 Acts as Functional RBP in the Macrophage Inflammation Response.Frontiers in molecular biosciences · 2021Article
- Mechanical Model of Nuclei Ordering in Drosophila Embryos Reveals Dilution of Stochastic Forces.Biophysical journal · 2018Article
- Depletion of kinesin-12, a myosin-IIB-interacting protein, promotes migration of cortical astrocytes.Journal of cell science · 2016Article
- The mechanical properties of early Drosophila embryos measured by high-speed video microrheology.Biophysical journal · 2015Article
- Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers.eLife · 2014Article
- The bipolar assembly domain of the mitotic motor kinesin-5.Nature communications · 2013Article
- Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Cytoplasmic microtubule sliding: An unconventional function of conventional kinesin.Communicative & integrative biology · 2010Article
- Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shape.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone.Seminars in cell & developmental biology · 2010Review
- Microtubule motors in eukaryotic spindle assembly and maintenance.Seminars in cell & developmental biology · 2010Review
- On and around microtubules: an overview.Molecular biotechnology · 2009Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The Drosophila syncytial embryo uses multiple astral mitotic spindles that are specialized for rapid mitosis. The homotetrameric kinesin-5, KLP61F contributes to various aspects of mitosis in this system, all of which are consistent with it exerting outward forces on spindle poles. In principle, kinesin-5 could accomplish this by (i) sliding microtubules (MTs), minus end leading, relative to a static spindle matrix or (ii) crosslinking and sliding apart adjacent pairs of antiparallel interpolar (ip) MTs. Here, I critically review data on the biochemistry of purified KLP61F, its localization and dynamic properties within spindles, and quantitative modeling of KLP61F function. While a matrix-based mechanism may operate in some systems, the work tends to support the latter "sliding filament" mechanism for KLP61F action in Drosophila embryo spindles. Cell Motil. Cytoskeleton 2009. (c) 2009 Wiley-Liss, Inc.
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