ArticleBiomedical microdevices2009
Fabrication and physical evaluation of a polymer-encapsulated paramagnetic probe for biomedical oximetry.
Article in Biomedical microdevices, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Electron paramagnetic resonance (EPR) meets drug delivery and biomaterials: a magnetic love story.Drug delivery and translational research · 2026Review
- A Flexible RF Coil Design (OxyTrack) for Oxygen Measurements in Body Cavities.Magnetic resonance in medicine · 2026Article
- OxyTrack: A Novel Needle Sensor for In Situ Oximetry.Magnetic resonance in medicine · 2026Article
- 3D Printing of Oxygen-Sensing ECM-Based Skin Graft for Personalized Treatment of Chronic Wounds-A Technological Proof of Concept.Journal of functional biomaterials · 2026Article
- Pulse and CW EPR Oximetry Using Oxychip in Gemcitabine-Treated Murine Pancreatic Tumors.Molecular imaging and biology · 2024Article
- OxyChip embedded with radio-opaque gold nanoparticles for anatomic registration and oximetry in tissues.Magnetic resonance in medicine · 2022Article
- The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia.Frontiers in pharmacology · 2022Review
- Evaluation of a Refined Implantable Resonator for Deep-Tissue EPR Oximetry in the Clinic.Applied magnetic resonance · 2021Article
- First-In-Human Study in Cancer Patients Establishing the Feasibility of Oxygen Measurements in Tumors Using Electron Paramagnetic Resonance With the OxyChip.Frontiers in oncology · 2021Article
- Development of an L-band rapid scan EPR digital console.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2019Article
- Oxygenic photosynthesis: EPR study of photosynthetic electron transport and oxygen-exchange, an overview.Cell biochemistry and biophysics · 2019Review
- Transcutaneous oxygen measurement in humans using a paramagnetic skin adhesive film.Magnetic resonance in medicine · 2019Article
- Wireless implantable coil with parametric amplification for in vivo electron paramagnetic resonance oximetric applications.Magnetic resonance in medicine · 2018Article
- In Vivo Molecular Electron Paramagnetic Resonance-Based Spectroscopy and Imaging of Tumor Microenvironment and Redox Using Functional Paramagnetic Probes.Antioxidants & redox signaling · 2018Review
- Skeletal Muscle Oxygenation Measured by EPR Oximetry Using a Highly Sensitive Polymer-Encapsulated Paramagnetic Sensor.Advances in experimental medicine and biology · 2016Article
- Clinical EPR: unique opportunities and some challenges.Academic radiology · 2014Review
- Advances in probes and methods for clinical EPR oximetry.Advances in experimental medicine and biology · 2014Review
- Noninvasive monitoring of small intestinal oxygen in a rat model of chronic mesenteric ischemia.Cell biochemistry and biophysics · 2013Article
- Repeated assessment of orthotopic glioma pO(2) by multi-site EPR oximetry: a technique with the potential to guide therapeutic optimization by repeated measurements of oxygen.Journal of neuroscience methods · 2012Article
- A molecular paramagnetic spin-doped biopolymeric oxygen sensor.Biosensors & bioelectronics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Lithium octa-n-butoxynaphthalocyanine (LiNc-BuO) is a promising probe for biological electron paramagnetic resonance (EPR) oximetry and is being developed for clinical use. However, clinical applicability of LiNc-BuO may be hindered by potential limitations associated with biocompatibility, biodegradation, and migration of individual crystals in tissue. To overcome these limitations, we have encapsulated LiNc-BuO crystals in polydimethyl siloxane (PDMS), an oxygen-permeable and bioinert polymer, to fabricate conveniently implantable and retrievable oxygen-sensing chips. Encapsulation was performed by a simple cast-molding process, giving appreciable control over size, shape, thickness and spin density of chips. The in vitro oxygen response of the chip was linear, reproducible, and not significantly different from that of unencapsulated crystals. Cast-molding of the structurally-flexible PDMS enabled the fabrication of chips with tailored spin densities, and ensured non-exposure of embedded LiNc-BuO, mitigating potential biocompatibility/toxicological concerns. Our results establish PDMS-encapsulated LiNc-BuO as a promising candidate for further biological evaluation and potential clinical application.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.