Evidence map›Paper›PMID 19291387›Full record

Trial reportJournal of abnormal child psychology2009

Stimulant treatment reduces lapses in attention among children with ADHD: the effects of methylphenidate on intra-individual response time distributions.

Sarah V Spencer, Larry W Hawk, Jerry B Richards, Keri Shiels, William E Pelham, James G Waxmonsky

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of abnormal child psychology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04964427 (The Effects of Methylphenidate), which is not on this map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04964427 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effects of Methylphenidate (MPH) and Non-invasive Brain Stimulation (tDCS) on Inhibitory Control Children With Attention-Deficit/Hyperactivity Disorder (ADHD)

TypeinterventionalSponsorBambino Gesù Hospital and Research InstituteRan2021 to 2022Enrolled26ConditionsAttention Deficit Hyperactivity DisorderArmsMethylphenidate, anodal tDCS, sham tDCS
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pharmacological Manipulations of Physiological Arousal and Sleep-Like Slow Waves Modulate Sustained Attention.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Trial
  5. Trial
  6. How do stimulant treatments for ADHD work? Evidence for mediation by improved cognition.Journal of child psychology and psychiatry, and allied disciplines · 2018
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Effects of stimulant medication, incentives, and event rate on reaction time variability in children with ADHD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011
    Trial
  12. Trial
  13. Trial
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Moderators and Other Predictors of Methylphenidate Response in Children and Adolescents with ADHD.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sarah V SpencerDepartment of Psychology, University at Buffalo, SUNY, Park Hall, Box 604110, Buffalo, NY 14260-4110, USA.
Larry W Hawk
Jerry B Richards
Keri Shiels
William E Pelham
James G Waxmonsky
University at Buffalo, State University of New York · US

Funding

Inhibitory control and clinical response in ADHDR01MH069434 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI HAWK, LARRY W · 2005 to 2009
$1.8M
NIMH NIH HHS MH069434NIMH NIH HHS R01 MH069434
6 · The paper itself

Abstract

Recent research has suggested that intra-individual variability in reaction time (RT) distributions of children with ADHD is characterized by a particularly large rightward skew that may reflect lapses in attention. The purpose of the study was to provide the first randomized, placebo-controlled test of the effects of the stimulant methylphenidate (MPH) on this tail and other RT distribution characteristics. Participants were 49 9- to 12-year-old children with ADHD. Children participated in a 3-day double-blind, placebo-controlled medication assessment during which they received long-acting MPH (Concerta), with the nearest equivalents of 0.3 and 0.6 mg/kg t.i.d. immediate-release MPH. Children completed a simple two-choice speeded discrimination task on and off of medication. Mode RT and deviation from the mode were used to examine the peak and skew, respectively, of RT distributions. MPH significantly reduced the peak and skew of RT distributions. Importantly, the two medication effects were uncorrelated suggesting that MPH works to improve both the speed and variability in responding. The improvement in variability with stimulant treatment is interpreted as a reduction in lapses in attention. This, in turn, may reflect stimulant enhancement of self-regulatory processes theorized to be at the core of ADHD.

Indexed as

AttentionAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildDiscrimination, PsychologicalDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMethylphenidateNew YorkReaction TimeTask Performance and AnalysisCentral Nervous System StimulantsMethylphenidate

Identifiers

PMID19291387
PMCPMC2709162
OpenAlexW2069028385

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.