Evidence map›Paper›PMID 19291323›Full record

ArticleImplementation science : IS2009

Fever, hyperglycaemia and swallowing dysfunction management in acute stroke: a cluster randomised controlled trial of knowledge transfer.

Sandy Middleton, Christopher Levi, Jeanette Ward, Jeremy Grimshaw, Rhonda Griffiths, Catherine D'Este, Simeon Dale, N Wah Cheung, Clare Quinn, Malcolm Evans and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Implementation science : IS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07627399 (Effectiveness of Implementing Best Care Practices in the Management of Patients With Acute Stroke in Conventional Hospitalization), which is not on this map. Cited by 12 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 5 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07627399 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of Implementing Best Care Practices in the Management of Patients With Acute Stroke in Conventional Hospitalization: A Cluster-Randomized, Open, Stepped-Wedge Controlled Trial.

TypeinterventionalSponsorUniversity of MalagaRan2026 to 2028Enrolled700ConditionsStroke, Acute Stroke, Ischemic Stroke, Hemorrhagic StrokeArmsBEST CARE ICTUS_HC BUNDLE
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Organised inpatient (stroke unit) care for stroke: network meta-analysis.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Pooled it
  4. Organised inpatient (stroke unit) care for stroke.The Cochrane database of systematic reviews · 2013
    Pooled it
  5. Pooled it
  6. Health risk factors in Australian Stroke Survivors: A latent class analysis.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2024
    Trial
  7. Trial
  8. Trial
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 2 countries.

Sandy MiddletonSt Vincents and Mater Health Sydney, Victoria St, Darlinghurst, 2010, NSW, Australia. Sandy.middleton@acu.edu.au
Christopher Levi
Jeanette Ward
Jeremy Grimshaw
Rhonda Griffiths
Catherine D'Este
Simeon Dale
N Wah Cheung
Clare Quinn
Malcolm Evans
Dominique Cadilhac
Heidelberg Repatriation Hospital · AUHunter Medical Research Institute · AUJohn Hunter Hospital · AUNational Centre for Clinical Research on Emerging Drugs · AUPrince of Wales Hospital · AUSt Vincent's Hospital Sydney · AUUniversity of Newcastle Australia · AUUniversity of Ottawa · CAWestern Sydney University · AUWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyperglycaemia, fever, and swallowing dysfunction are poorly managed in the admission phase of acute stroke, and patient outcomes are compromised. Use of evidence-based guidelines could improve care but have not been effectively implemented. Our study aims to develop and trial an intervention based on multidisciplinary team-building to improve management of fever, hyperglycaemia, and swallowing dysfunction in patients following acute stroke. METHODS AND

designMetropolitan acute stroke units (ASUs) located in New South Wales, Australia will be stratified by service category (A or B) and, within strata, by baseline patient recruitment numbers (high or low) in this prospective, multicentre, single-blind, cluster randomised controlled trial (CRCT). ASUs then will be randomised independently to either intervention or control groups. ASUs allocated to the intervention group will receive: unit-based workshops to identify local barriers and enablers; a standardised core education program; evidence-based clinical treatment protocols; and ongoing engagement of local staff. Control group ASUs will receive only an abridged version of the National Clinical Guidelines for Acute Stroke Management. The following outcome measures will be collected at 90 days post-hospital admission: patient death, disability (modified Rankin Score); dependency (Barthel Index) and Health Status (SF-36). Additional measures include: performance of swallowing screening within 24 hours of admission; glycaemic control and temperature control. DISCUSSION: This is a unique study of research transfer in acute stroke. Providing optimal inpatient care during the admission phase is essential if we are to combat the rising incidence of debilitating stroke. Our CRCT will also allow us to test interventions focussed on multidisciplinary ASU teams rather than individual disciplines, an imperative of modern hospital services.

trial registrationAustralia New Zealand Clinical Trial Registry (ANZCTR) No: ACTRN12608000563369.

Identifiers

PMID19291323
PMCPMC2663544
OpenAlexW2079428464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.