ArticlePloS one2009
Serotonin increases cilia-driven particle transport via an acetylcholine-independent pathway in the mouse trachea.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02559284 (A Comparative, Multicenter and Randomized Study Evaluating the Safety and Efficacy of RESPIMER® Netiflow® Versus Saline Solutions During Nasal Irrigation Following Bilateral Ethmoidectomy in the Treatment of Nasal Polyposis.), which is not on this map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Comparative, Multicenter and Randomized Study Evaluating the Safety and Efficacy of RESPIMER® Netiflow® Versus Saline Solutions During Nasal Irrigation Following Bilateral Ethmoidectomy in the Treatment of Nasal Polyposis.
Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Characterization of catecholaminergic and serotonergic pathways in the trachea of the chicken and turkey.Poultry science · 2026Article
- Dynamics and emergence of metachronal waves in the ciliary band of a metazoan larva.Science advances · 2025Article
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- The Dual Role of the Airway Epithelium in Asthma: Active Barrier and Regulator of Inflammation.Cells · 2023Review
- Mucociliary Wnt signaling promotes cilia biogenesis and beating.Nature communications · 2023Article
- Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways.Biomedical optics express · 2022Article
- Echinocandins Accelerate Particle Transport Velocity in the Murine Tracheal Epithelium: Dependency on Intracellular CaAntimicrobial agents and chemotherapy · 2021Article
- Neuronal coordination of motile cilia in locomotion and feeding.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Mucociliary Clearance in Mice Measured by Tracking Trans-tracheal Fluorescence of Nasally Aerosolized Beads.Scientific reports · 2018Article
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- Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons.Particle and fibre toxicology · 2017Article
- ATP4a is required for development and function of the Xenopus mucociliary epidermis - a potential model to study proton pump inhibitor-associated pneumonia.Developmental biology · 2015Article
- Microscale imaging of cilia-driven fluid flow.Cellular and molecular life sciences : CMLS · 2015Review
- Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium.PloS one · 2015Article
- Article
- Ozone exposure alters serotonin and serotonin receptor expression in the developing lung.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Molecular signaling and targets from itch: lessons for cough.Cough (London, England) · 2013Article
- Neuronal control of pedal sole cilia in the pond snail Lymnaea stagnalis appressa.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- Time-dependent changes in nasal ciliary beat frequency.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMucociliary clearance in the airways is driven by the coordinated beating of ciliated cells. Classical neuromediators such as noradrenalin and acetylcholine increase ciliary beat frequency and thus cilia-driven transport. Despite the fact that the neuromediator serotonin is ciliostimulatory in invertebrates and has been implied in releasing acetylcholine from the airway epithelium, its role in regulating cilia function in vertebrate airways is not established. METHODOLOGY/PRINCIPAL
findingsWe examined the effects of serotonin on ciliary beat frequency and cilia-driven particle transport in the acutely excised submerged mouse trachea and determined the sources of serotonin in this tissue by immunohistochemistry. Serotonin (100 microM) increased cilary beat frequency (8.9+/-1.2 Hz to 17.0+/-2.7 Hz) and particle transport speed (38.9+/-4.6 microm/s to 83.4+/-8.3 microm/s) to an extent that was comparable to a supramaximal dose of ATP. The increase in particle transport speed was totally prevented by methysergide (100 microM). Blockade of muscarinic receptors by atropine (1 microM) did not reduce the effect of serotonin, although it was effective in preventing the increase in particle transport speed mediated by muscarine (100 microM). Immunohistochemistry demonstrated serotonin in mast cells pointing towards mast cells and platelets as possible endogenous sources of serotonin. CONCLUSIONS/SIGNIFICANCE: These results indicate that serotonin is a likely endogenous mediator that can increase cilia-driven transport independent from acetylcholine during activation of mast cells and platelets.
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