ArticleHypertension (Dallas, Tex. : 1979)2009
Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome.
Article in Hypertension (Dallas, Tex. : 1979), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Impaired acetylcholine-induced cutaneous vasodilation in young smokers: roles of nitric oxide and prostanoids.American journal of physiology. Heart and circulatory physiology · 2013Trial
- Correlation between orthostatic intolerance in children and levels of ACE2-Ang(1-7)-Mas axis and vitamin D.Frontiers in pediatrics · 2025Article
- Autoimmunity in Syndromes of Orthostatic Intolerance: An Updated Review.Journal of personalized medicine · 2024Review
- Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1.Autonomic neuroscience : basic & clinical · 2021Article
- Cutaneous manifestations of orthostatic intolerance syndromes.International journal of women's dermatology · 2021Article
- [Diagnostic Application of Invasive Cardiopulmonary Exercise Test in Patients with Unexplained Dyspnea].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021Article
- Infectious mononucleosis complicated by peritonsillar abscess and postural orthostatic tachycardia syndrome: A case report.SAGE open medical case reports · 2020Article
- Local angiotensin-(1-7) administration improves microvascular endothelial function in women who have had preeclampsia.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Orthostatic Circulatory Disorders: From Nosology to Nuts and Bolts.American journal of hypertension · 2016Review
- Passive heat therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide-dependent dilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing.Pulmonary circulation · 2016Article
- Distinct neurohumoral biomarker profiles in children with hemodynamically defined orthostatic intolerance may predict treatment options.American journal of physiology. Heart and circulatory physiology · 2016Article
- Dermatological Manifestations of Postural Tachycardia Syndrome Are Common and Diverse.Journal of clinical neurology (Seoul, Korea) · 2016Article
- Article
- Blunted cerebral blood flow velocity in response to a nitric oxide donor in postural tachycardia syndrome.American journal of physiology. Heart and circulatory physiology · 2014Article
- Postural orthostatic tachycardia syndrome: a dermatologic perspective and successful treatment with losartan.The Journal of clinical and aesthetic dermatology · 2014Article
- Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers.American journal of physiology. Heart and circulatory physiology · 2014Article
- Neuronal and hormonal perturbations in postural tachycardia syndrome.Frontiers in physiology · 2014Review
- Common syndromes of orthostatic intolerance.Pediatrics · 2013Review
- Modulation of the axon-reflex response to local heat by reactive oxygen species in subjects with chronic fatigue syndrome.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Postural tachycardia syndrome (POTS) is associated with increased plasma angiotensin II (Ang II). Ang II administered in the presence of NO synthase inhibition with nitro-L-arginine (NLA) and Ang II type 1 receptor blockade with losartan produces vasodilation during local heating in controls. We tested whether this angiotensin-mediated vasodilation occurs in POTS and whether it is related to angiotensin-converting enzyme 2 (ACE2) and Ang-(1-7). We used local cutaneous heating to 42 degrees C and laser Doppler Flowmetry to assess NO-dependent conductance at 4 calf sites in 12 low-flow POTS and in 12 control subjects 17.6 to 25.5 years of age. We perfused Ringer's solution through intradermal microdialysis catheters and performed local heating. We perfused one catheter with NLA (10 mmol/L)+losartan (2 microg/L) and repeated heating, and NLA+losartan+Ang II (10 micromol/L), repeating heating a third time. A second catheter received NLA+losartan+Ang II, heated, perfused NLA+losartan+Ang II+DX600 (1 mmol/L; a selective ACE2 inhibitor), and reheated. A third catheter received NLA+losartan+Ang II, heated, perfused NLA+losartan+Ang II+Ang-(1-7) (100 micromol/L), and reheated. The fourth catheter received Ang-(1-7) then reheated a second time only. Angiotensin-mediated vasodilation was present in control but not POTS. Ang-mediated dilation was eliminated by DX600, indicating an ACE2-related effect. Ang-mediated vasodilation was restored in POTS by Ang-(1-7). When administered alone during locally mediated heating, Ang-(1-7) improved the NO-dependent local heating response. ACE2 effects are blunted in low-flow POTS and restored by the ACE2 product Ang-(1-7). Data imply impaired catabolism of Ang II through the ACE2 pathway. Vasoconstriction in POTS may result from a reduction in Ang-(1-7) and an increase in Ang II.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.