ArticleThe Journal of physiology2009
Functional K(ATP) channels in the rat retinal microvasculature: topographical distribution, redox regulation, spermine modulation and diabetic alteration.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
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- Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- KATP Opener Attenuates Diabetic-Induced Müller Gliosis and Inflammation by Modulating Kir6.1 in Microglia.Investigative ophthalmology & visual science · 2021Article
- The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes.Frontiers in cellular neuroscience · 2020Review
- Role of KPflugers Archiv : European journal of physiology · 2019Article
- Purinergic Vasotoxicity: Role of the Pore/Oxidant/KVision (Basel, Switzerland) · 2018Article
- Role of ion channels in the functional response of conjunctival goblet cells to dry eye.American journal of physiology. Cell physiology · 2018Article
- Role of capillary pericytes in the integration of spontaneous CaThe Journal of physiology · 2018Article
- Bioelectric impact of pathological angiogenesis on vascular function.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Spontaneous activity in the microvasculature of visceral organs: role of pericytes and voltage-dependent Ca(2+) channels.The Journal of physiology · 2016Review
- Catalase therapy corrects oxidative stress-induced pathophysiology in incipient diabetic retinopathy.Investigative ophthalmology & visual science · 2015Article
- Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment.Annals of the New York Academy of Sciences · 2014Review
- Arginase in retinopathy.Progress in retinal and eye research · 2013Review
- The electrotonic architecture of the retinal microvasculature: diabetes-induced alteration.Neurochemistry international · 2012Article
- Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease.Progress in retinal and eye research · 2012Review
- Retinovascular physiology and pathophysiology: new experimental approach/new insights.Progress in retinal and eye research · 2012Review
- Vulnerability of the retinal microvasculature to oxidative stress: ion channel-dependent mechanisms.American journal of physiology. Cell physiology · 2012Article
- Vulnerability of the retinal microvasculature to hypoxia: role of polyamine-regulated K(ATP) channels.Investigative ophthalmology & visual science · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The essential task of the circulatory system is to match blood flow to local metabolic demand. However, much remains to be learned about this process. To better understand how local perfusion is regulated, we focused on the functional organization of the retinal microvasculature, which is particularly well adapted for the local control of perfusion. Here, we assessed the distribution and regulation of functional K(ATP) channels whose activation mediates the hyperpolarization induced by adenosine. Using microvascular complexes freshly isolated from the rat retina, we found a topographical heterogeneity in the distribution of functional K(ATP) channels; capillaries generate most of the K(ATP) current. The initiation of K(ATP)-induced responses in the capillaries supports the concept that the regulation of retinal perfusion is highly decentralized. Additional study revealed that microvascular K(ATP) channels are redox sensitive, with oxidants increasing their activity. Furthermore, the oxidant-mediated activation of these channels is driven by the polyamine spermine, whose catabolism produces oxidants. In addition, our observation that spermine-dependent oxidation occurs predominately in the capillaries accounts for why they generate most of the K(ATP) current detected in retinal microvascular complexes. Here, we also analysed retinal microvessels of streptozotocin-injected rats. We found that soon after the onset of diabetes, an increase in spermine-dependent oxidation at proximal microvascular sites boosts their K(ATP) current and thereby virtually eliminates the topographical heterogeneity of functional K(ATP) channels. We conclude that spermine-dependent oxidation is a previously unrecognized mechanism by which this polyamine modulates ion channels; in addition to a physiological role, spermine-dependent oxidation may also contribute to microvascular dysfunction in the diabetic retina.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.