ArticleAntimicrobial agents and chemotherapy2009
The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects.Frontiers in chemistry · 2022Review
- Advance of structural modification of nucleosides scaffold.European journal of medicinal chemistry · 2021Review
- GA-Hecate antiviral properties on HCV whole cycle represent a new antiviral class and open the door for the development of broad spectrum antivirals.Scientific reports · 2018Article
- Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry.Scientific reports · 2017Article
- New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.Bioorganic & medicinal chemistry · 2017Article
- Hepatitis C virus in vitro replication is efficiently inhibited by acridone Fac4.The Journal of general virology · 2017Article
- Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90.Cell stress & chaperones · 2017Article
- Article
- Multiple effects of toxins isolated from Crotalus durissus terrificus on the hepatitis C virus life cycle.PloS one · 2017Article
- Foot-and-mouth disease virus genome replication is unaffected by inhibition of type III phosphatidylinositol-4-kinases.The Journal of general virology · 2016Article
- Early events in the generation of autophagosomes are required for the formation of membrane structures involved in hepatitis C virus genome replication.The Journal of general virology · 2016Article
- Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease.Antiviral research · 2015Article
- Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease.Antiviral research · 2015Article
- Requirement for chloride channel function during the hepatitis C virus life cycle.Journal of virology · 2015Article
- Natural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro.Antiviral research · 2015Article
- Evaluation of canonical siRNA and Dicer substrate RNA for inhibition of hepatitis C virus genome replication--a comparative study.PloS one · 2015Article
- Vitamin D Metabolites Inhibit Hepatitis C Virus and Modulate Cellular Gene Expression.Journal of virology & antiviral research · 2014Article
- Hepatitis C virus-induced autophagy is independent of the unfolded protein response.Journal of virology · 2012Article
- Evaluation of ITX 5061, a scavenger receptor B1 antagonist: resistance selection and activity in combination with other hepatitis C virus antivirals.The Journal of infectious diseases · 2012Article
- Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication.Bioorganic & medicinal chemistry · 2011Article
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6 authors.
Funding
Abstract
The octadecyloxyethyl (ODE) and hexadecyloxypropyl (HDP) esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) are potent inhibitors of orthopoxvirus, herpesvirus, human immunodeficiency virus type 1, and hepatitis B virus replication in vitro. HDP and ODE esters of (S)-HPMPA and (R)-HPMPA were evaluated for their activity in hepatitis C virus (HCV) replicon assays using luciferase (1B and 2A replicons) or RNA (1B) quantification. The ODE ester of (S)-HPMPA [ODE-(S)-HPMPA] was the most active compound, with 50% effective concentrations (EC(50)s) in the 0.69 to 1.31 microM range. HDP and ODE esters of (R)-HPMPA were severalfold less active, while (S)-HPMPA and (R)-HPMPA were inactive. In genotype 1A and 1B replicons analyzed by HCV RNA analysis, ODE-(S)-HPMPA was the most active compound, with EC(50)s of 1.8 and 2.1 microM, respectively.
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