ArticleInfection and immunity2009
Genetics and virulence association of the Shigella flexneri sit iron transport system.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Microbial Characteristics of the Extrinsic Black Stain in Primary Dentition.International dental journal · 2026Article
- The dual implications of iron homeostasis as a bacterial threat: its roles in virulence and antimicrobial resistance.Archives of microbiology · 2025Review
- Infective endocarditis caused byThe Journal of international medical research · 2025Article
- Pushing boundaries: mechanisms enabling bacterial pathogens to spread between cells.Infection and immunity · 2024Review
- (p)ppGpp is required for virulence ofInfection and immunity · 2024Article
- Iron Transport and Metabolism in Escherichia, Shigella, and Salmonella.EcoSal Plus · 2021Article
- Ecology, Structure, and Evolution ofAnnual review of virology · 2020Review
- Article
- Pathogenicity Factors of Genomic Islands in Intestinal and ExtraintestinalFrontiers in microbiology · 2020Review
- A large self-transmissible resistance plasmid from Nigeria contains genes that ameliorate a carrying cost.Scientific reports · 2019Article
- Global transcriptomic analyses of Salmonella enterica in Iron-depleted and Iron-rich growth conditions.BMC genomics · 2019Article
- Formate PromotesmBio · 2018Article
- Pathogenomics of Virulence Traits ofFrontiers in microbiology · 2018Article
- The genomic signatures of Shigella evolution, adaptation and geographical spread.Nature reviews. Microbiology · 2016Review
- Shigella Iron Acquisition Systems and their Regulation.Frontiers in cellular and infection microbiology · 2016Review
- Evaluation of Gallium Citrate Formulations against a Multidrug-Resistant Strain of Klebsiella pneumoniae in a Murine Wound Model of Infection.Antimicrobial agents and chemotherapy · 2015Article
- Strategies of Intracellular Pathogens for Obtaining Iron from the Environment.BioMed research international · 2015Review
- Regulation of iron transport systems in Enterobacteriaceae in response to oxygen and iron availability.Journal of inorganic biochemistry · 2014Review
- Article
- Analysis of the proteome of intracellular Shigella flexneri reveals pathways important for intracellular growth.Infection and immunity · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The sit-encoded iron transport system is present within pathogenicity islands in all Shigella spp. and some pathogenic Escherichia coli strains. The islands contain numerous insertion elements and sequences with homology to bacteriophage genes. The Shigella flexneri sit genes can be lost as a result of deletion within the island. The formation of deletions was dependent upon RecA and occurred at relatively high frequency. This suggests that the sit region is inherently unstable, yet sit genes are maintained in all of the clinical isolates tested. Characterization of the sitABCD genes in S. flexneri indicates that they encode a ferrous iron transport system, although the genes are induced aerobically. The sit genes provide a competitive advantage to S. flexneri growing within epithelial cells, and a sitA mutant is outcompeted by the wild type in cultured epithelial cells. The Sit system is also required for virulence in a mouse lung model. The sitA mutant was able to infect the mice and induce a protective immune response but was avirulent compared to its wild-type parent strain.
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Registered trials
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