ArticleMethods in enzymology2009
Energetic profiling of protein folds.
Article in Methods in enzymology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Ensemble molecular mimicry correlates with antibody cross-reactivity in proteome-wide studies.Frontiers in immunology · 2026Article
- Conserved allosteric ensembles in disordered proteins using TROSY/anti-TROSY RBiophysical journal · 2021Article
- Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The role of key residues in structure, function, and stability of cytochrome-c.Cellular and molecular life sciences : CMLS · 2014Review
- Prediction of protein relative enthalpic stability from molecular dynamics simulations of the folded and unfolded states.Biophysical journal · 2012Article
- Protein hydrogen exchange: testing current models.Protein science : a publication of the Protein Society · 2012Article
- Quantitative assessment of protein structural models by comparison of H/D exchange MS data with exchange behavior accurately predicted by DXCOREX.Journal of the American Society for Mass Spectrometry · 2012Article
- The role of protein conformational fluctuations in allostery, function, and evolution.Biophysical chemistry · 2011Review
- Investigating homology between proteins using energetic profiles.PLoS computational biology · 2010Article
- An energetic representation of protein architecture that is independent of primary and secondary structure.Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Current protein classification methods treat high-resolution structures as static entities. However, experiments have well documented the dynamic nature of proteins. With knowledge that thermodynamic fluctuations around the high-resolution structure contribute to a more physically accurate and biologically meaningful picture of a protein, the concept of a protein's energetic profile is introduced. It is demonstrated on a large scale that energetic profiles are both diagnostic of a protein fold and evolutionarily relevant. Development of Structural Thermodynamic Ensemble-based Protein Homology (STEPH), an algorithm that searches for local similarities between energetic profiles, constitutes a first step towards a long-term goal of our laboratory to integrate thermodynamic information into protein-fold classification approaches.
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