ArticleBiophysical journal2009
Nonequilibrium self-assembly of a filament coupled to ATP/GTP hydrolysis.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Many will enter, few will win: Cost and sensitivity of exploratory dynamics.Biophysical journal · 2026Article
- Hydrolysis-dependent severing tunes internal monomeric heterogeneity to shape actin length distributions.bioRxiv : the preprint server for biology · 2025Article
- The effect of motor-induced shaft dynamics on microtubule stability and length.Biophysical journal · 2023Article
- Effects of random hydrolysis on biofilament length distributions in a shared subunit pool.Biophysical journal · 2022Article
- Effects of length-dependent positive feedback on length distributions of microtubules undergoing hydrolysis.Journal of biosciences · 2022Article
- Atomistic molecular dynamics simulations of tubulin heterodimers explain the motion of a microtubule.European biophysics journal : EBJ · 2021Article
- Article
- A minimal conformational switching-dependent model for amyloid self-assembly.Scientific reports · 2016Article
- Profilin Interaction with Actin Filament Barbed End Controls Dynamic Instability, Capping, Branching, and Motility.Developmental cell · 2016Article
- Force-induced dynamical properties of multiple cytoskeletal filaments are distinct from that of single filaments.PloS one · 2014Article
- Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels.Nature cell biology · 2013Article
- Microtubule dynamic instability: a new model with coupled GTP hydrolysis and multistep catastrophe.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Sensor potency of the moonlighting enzyme-decorated cytoskeleton: the cytoskeleton as a metabolic sensor.BMC biochemistry · 2013Article
- Random hydrolysis controls the dynamic instability of microtubules.Biophysical journal · 2012Article
- The mechanisms of microtubule catastrophe and rescue: implications from analysis of a dimer-scale computational model.Molecular biology of the cell · 2012Article
- A theoretical analysis of filament length fluctuations in actin and other polymers.Journal of mathematical biology · 2011Article
- Dynamic instability of a growing adsorbed polymorphic filament.Biophysical journal · 2011Article
- Role of ATP-hydrolysis in the dynamics of a single actin filament.Biophysical journal · 2010Article
- A theory of microtubule catastrophes and their regulation.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We study the stochastic dynamics of growth and shrinkage of single actin filaments or microtubules taking into account insertion, removal, and ATP/GTP hydrolysis of subunits. The resulting phase diagram contains three different phases: two phases of unbounded growth: a rapidly growing phase and an intermediate phase, and one bounded growth phase. We analyze all these phases, with an emphasis on the bounded growth phase. We also discuss how hydrolysis affects force-velocity curves. The bounded growth phase shows features of dynamic instability, which we characterize in terms of the time needed for the ATP/GTP cap to disappear as well as the time needed for the filament to reach a length of zero (i.e., to collapse) for the first time. We obtain exact expressions for all these quantities, which we test using Monte Carlo simulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.