ArticleBiophysical journal2009
Rigidity-dependent cross talk between integrin and cadherin signaling.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Force-dependent focal adhesion assembly and disassembly: A computational study.PLoS computational biology · 2023Article
- Paxillin tunes the relationship between cell-matrix and cell-cell adhesions to regulate stiffness-dependent dentinogenesis.Regenerative biomaterials · 2023Article
- Intrinsic cell rheology drives junction maturation.Nature communications · 2022Article
- Mechanisms of the Osteogenic Switch of Smooth Muscle Cells in Vascular Calcification: WNT Signaling, BMPs, Mechanotransduction, and EndMT.Bioengineering (Basel, Switzerland) · 2020Review
- A traction force threshold signifies metastatic phenotypic change in multicellular epithelia.Soft matter · 2019Article
- Force localization modes in dynamic epithelial colonies.Molecular biology of the cell · 2018Article
- Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells.Cold Spring Harbor perspectives in biology · 2017Review
- Epithelial self-healing is recapitulated by a 3D biomimetic E-cadherin junction.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells.Nature materials · 2016Article
- Constructing modular and universal single molecule tension sensor using protein G to study mechano-sensitive receptors.Scientific reports · 2016Article
- Running with neighbors: coordinating cell migration and cell-cell adhesion.Current opinion in cell biology · 2015Review
- Force measurement tools to explore cadherin mechanotransduction.Cell communication & adhesion · 2014Review
- Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions.The Journal of cell biology · 2014Article
- Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility.Molecular and cellular biology · 2014Article
- JNK is a novel regulator of intercellular adhesion.Tissue barriers · 2013Review
- Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Micro- and nanoscale engineering of cell signaling.Annual review of biomedical engineering · 2013Review
- E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- E-cadherin-dependent stimulation of traction force at focal adhesions via the Src and PI3K signaling pathways.Biophysical journal · 2012Article
- Biochemical and mechanical extracellular matrix properties dictate mammary epithelial cell motility and assembly.Biotechnology journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Integrin-cadherin cross talk is an important aspect of cell function. We explored this signaling using substrates micropatterned with islands of fibronectin surrounded by E-cadherin, capturing the segregation of these signals in normal tissue. While MDCK cells were able to concurrently form adhesive structures with these two proteins, engagement of fibronectin by MCF-7 cells, an adenocarcinoma cell line, inhibited response of these cells to E-cadherin. We further demonstrated that this inhibition is rigidity dependent; on soft elastomer substrates with Young's modulus in the range of tens of kiloPascals, MCF-7 cells were able to engage both integrin and cadherin ligands.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.