ReviewWorld journal of surgery2009
What symptom improvement can be expected after operation for primary hyperparathyroidism?
Review in World journal of surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Patient-reported outcome measures for primary hyperparathyroidism: a systematic review of measurement properties.Health and quality of life outcomes · 2024Pooled it
- Pooled it
- Pooled it
- Osteitis fibrosa cystica recovery following parathyroidectomy for primary hyperparathyroidism: a case series and review of literature.JBMR plus · 2025Review
- Neuropsychiatric Comorbidity in Primary Hyperparathyroidism Before and After Parathyroidectomy: A Population Study.World journal of surgery · 2022Article
- Insights into Cognitive Brain Health in Chronic Kidney Disease.Gerontology & geriatrics : research · 2022Article
- Parathyroid Hormone Disturbances in Postmenopausal Women with Distal Forearm Fracture.World journal of surgery · 2022Article
- Serum Inflammation-based Scores in Endocrine Tumors.The Journal of clinical endocrinology and metabolism · 2021Review
- [Diagnostics and treatment of primary hyperparathyroidism].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2017Article
- Improving diagnostic recognition of primary hyperparathyroidism with machine learning.Surgery · 2017Article
- Surgical treatment of patients with mildly elevated parathormone and calcium levels.World journal of surgery · 2014Article
- Association between parathyroid hormone levels and inflammatory markers among US adults.Mediators of inflammation · 2014Article
- Multigland disease and slower decline in intraoperative PTH characterize mild primary hyperparathyroidism.Annals of surgical oncology · 2013Article
- Development of a new tool for assessing health-related quality of life in patients with primary hyperparathyroidism.Health and quality of life outcomes · 2013Article
- Minimally invasive parathyroid surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- Changes in swallowing-related quality of life after parathyroidectomy for hyperparathyroidism: a prospective cohort study.The oncologist · 2012Article
- Persistent symptomatic improvement in the majority of patients undergoing parathyroidectomy for primary hyperparathyroidism.Langenbeck's archives of surgery · 2010Article
- Long-term symptom relief from primary hyperparathyroidism following minimally invasive parathyroidectomy.World journal of surgery · 2010Article
- Parathyroidectomy: is vitamin D a player for a good outcome?Journal of medicine and lifeReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe only cure for primary hyperparathyroidism (pHPT) is operative resection of the parathyroid gland(s) responsible for the disease. The 1990 National Institute of Health's (NIH) consensus development conference on asymptomatic pHPT and its subsequent workshop in 2001 established which clinical criteria warranted parathyroidectomy (PTx) versus observation. While there is no debate that these NIH criteria capture a group of patients likely to benefit from PTx, there is concern that these guidelines miss a significant percentage of pHPT patients who actually are symptomatic. Unfortunately, these additional symptoms are often subtle, nonspecific, not traditionally measured, frequently not assessed or considered in this patient population, and are usually attributed to other diagnoses or simply advanced age.
methodsAn evidence-based literature review was performed assessing symptoms and clinical conditions associated with bone, neuropsychiatry, cognition, quality of life, and the neuromuscular system. The level of evidence and grade of recommendations were assigned to key studies to help determine recommendations regarding indications and potential benefits of parathyroidectomy (PTx).
resultsSymptoms ranging from decreased bone mineral density, increased fracture risk, neuropsychiatric symptoms and cognitive changes, lower quality of life, and neuromuscular symptoms were found to be associated with pHPT. The effects of PTx on these symptoms was addressed in a variety of studies that varied in quality.
conclusionAlthough there are few Level I randomized clinical trials addressing the benefit of PTx in patients with pHPT, there are supportive data to suggest that most patients with pHPT would benefit from operative cure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.