ArticleJournal of assisted reproduction and genetics2009
Evidence that human blastomere cleavage is under unique cell cycle control.
Article in Journal of assisted reproduction and genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Identifying a rare mechanism: double parallel trisomy rescue leading to combined segmental and whole-chromosome mosaicism in an IVF-derived embryo.Journal of assisted reproduction and genetics · 2025Article
- Microarray evidence that 8-cell human embryos express some hormone family members including oxytocin.Journal of assisted reproduction and genetics · 2024Article
- The physiological and pathological mechanisms of early embryonic development.Fundamental research · 2022Review
- Haplotype-aware inference of human chromosome abnormalities.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Next-generation sequencing analysis of each blastomere in good-quality embryos: insights into the origins and mechanisms of embryonic aneuploidy in cleavage-stage embryos.Journal of assisted reproduction and genetics · 2020Article
- Sperm DNA damage causes genomic instability in early embryonic development.Science advances · 2020Article
- The "life code": A theory that unifies the human life cycle and the origin of human tumors.Seminars in cancer biology · 2020Review
- Human germline genome editing.Nature cell biology · 2019Review
- Mosaicism in Preimplantation Human Embryos: When Chromosomal Abnormalities Are the Norm.Trends in genetics : TIG · 2017Review
- Early human embryos are naturally aneuploid-can that be corrected?Journal of assisted reproduction and genetics · 2017Review
- On becoming accepting of the imperfectionsin mammalian embryogenesis.Journal of assisted reproduction and genetics · 2016Article
- Differentially expressed genes in preimplantation human embryos: potential candidate genes for blastocyst formation and implantation.Journal of assisted reproduction and genetics · 2016Article
- Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells.Stem cells and development · 2016Article
- Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences.Cell and tissue research · 2016Review
- Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells.Nature structural & molecular biology · 2013Article
- Global gene expression profiling of individual human oocytes and embryos demonstrates heterogeneity in early development.PloS one · 2013Article
- Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage.Nature biotechnology · 2010Article
- Genome-wide microarray evidence that 8-cell human blastomeres over-express cell cycle drivers and under-express checkpoints.Journal of assisted reproduction and genetics · 2010Article
- Differential expression of the circadian clock in maternal and embryonic tissues of mice.PloS one · 2010Article
- Statistics of protein-DNA binding and the total number of binding sites for a transcription factor in the mammalian genome.BMC genomics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo understand the molecular pathways that control early human embryo development.
methodsImproved methods of linear amplification of mRNAs and whole human genome microarray analyses were utilized to characterize gene expression in normal appearing 8-Cell human embryos, in comparison with published microarrays of human fibroblasts and pluripotent stem cells.
resultsMany genes involved in circadian rhythm and cell division were over-expressed in the 8-Cells. The cell cycle checkpoints, RB and WEE1, were silent on the 8-Cell arrays, whereas the recently described tumor suppressor, UHRF2, was up-regulated >10-fold, and the proto-oncogene, MYC, and the core element of circadian rhythm, CLOCK, were elevated up to >50-fold on the 8-Cell arrays.
conclusionsThe canonical G1 and G2 cell cycle checkpoints are not active in totipotent human blastomeres, perhaps replaced by UHRF2, MYC, and intracellular circadian pathways, which may play important roles in early human development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.