Trial reportPsychopharmacology2009
Comparison of ketanserin, buspirone and propranolol on arousal, pupil size and autonomic function in healthy volunteers.
Trial report in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.Psychopharmacology · 2012Pooled it
- Disentangling the roles of dopamine and noradrenaline in the exploration-exploitation tradeoff during human decision-making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Ketanserin Reverses the Acute Response to LSD in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Participants.The international journal of neuropsychopharmacology · 2023Trial
- Distinct Roles of Dopamine and Noradrenaline in Incidental Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Trial
- Pharmacology of ayahuasca administered in two repeated doses.Psychopharmacology · 2012Trial
- Human complex exploration strategies are enriched by noradrenaline-modulated heuristics.eLife · 2021Article
- Functional Organization of the Sympathetic Pathways Controlling the Pupil: Light-Inhibited and Light-Stimulated Pathways.Frontiers in neurology · 2018Review
- Altered pupillary light response scales with disease severity in migrainous photophobia.Cephalalgia : an international journal of headache · 2017Article
- Mu opioid mediated discriminative-stimulus effects of tramadol: an individual subjects analysis.Journal of the experimental analysis of behavior · 2015Article
- Acute serotonin 2A receptor blocking alters the processing of fearful faces in the orbitofrontal cortex and amygdala.Journal of psychopharmacology (Oxford, England) · 2013Article
- Association between pupillometric sleepiness measures and sleep latency derived by MSLT in clinically sleepy patients.Environmental health and preventive medicine · 2013Article
- Dysregulation of the autonomous nervous system in patients with temporomandibular disorder: a pupillometric study.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe human pupil may be a suitable physiological test system for the assessment of excessive daytime sleepiness (EDS), but pupillometric assessment could be confounded by medication for comorbid hypertension and mood disorders.
objectivesWe examined the profile of the 5HT-2/alpha1/H1 antagonist ketanserin, the 5HT1a agonist buspirone and the beta adrenoceptor antagonist propranolol on pupillary and other measures of arousal. MATERIALS AND
methodsKetanserin (20 mg), buspirone (10 mg) and propranolol (40 mg) were administered in three independent experiments according to a crossover, placebo-controlled, double-blind design. Resting pupil diameter (RPD) was sampled over 5-min in darkness with infrared pupillometry. Tests also included critical flicker fusion frequency (CFFF), visual analogue scales (VAS), the pupillary light reflex and heart rate/blood pressure.
resultsKetanserin reduced RPD, CFFF, VAS-rated arousal and blood pressure and increased the light reflex amplitude. Buspirone reduced RPD and blood pressure. Propranolol reduced heart rate but had no effects on pupillary functions or any arousal measure.
conclusionsKetanserin but not propranolol had a fully sedative profile and may confound pupillometric assessment of EDS. Beta adrenergic receptors do not appear to participate in arousal and pupillary functions, while 5HT1a receptors reduce pupil size without affecting arousal. Pupil size may not be used unequivocally as an index of the level of alertness in the case of drug-induced changes, when drugs interfere with the central pupil control mechanism in ways that are unrelated to their effects on arousal.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.