ArticleStudies in mycology2008
HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi.
Article in Studies in mycology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Sensing and Responding to Hypersaline Conditions and the HOG Signal Transduction Pathway in Fungi Isolated from Hypersaline Environments:Journal of fungi (Basel, Switzerland) · 2021Review
- The extremely halotolerant black yeastIMA fungus · 2019Article
- Development of a plasmid free CRISPR-Cas9 system for the genetic modification of Mucor circinelloides.Scientific reports · 2017Article
- The Proteome and Lipidome of Thermococcus kodakarensis across the Stationary Phase.Archaea (Vancouver, B.C.) · 2016Article
- Transcription of the three HMG-CoA reductase genes of Mucor circinelloides.BMC microbiology · 2014Article
- Lovastatin-enriched rice straw enhances biomass quality and suppresses ruminal methanogenesis.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
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Abstract
The activity and level of HMG-CoA reductase (HMGR) were addressed in halophilic fungi isolated from solar saltpans. Representative fungi belonging to the orders Dothideales, Eurotiales and Wallemiales have a specific pattern of HMGR regulation, which differs from salt-sensitive and moderately salt-tolerant yeasts. In all of the halophilic fungi studied, HMGR amounts and activities were the lowest at optimal growth salinity and increased under hyposaline and hypersaline conditions. This profile paralleled isoprenylation of cellular proteins in H. werneckii. Inhibition of HMGR in vivo by lovastatin impaired the halotolerant character. HMGR may thus serve as an important molecular marker of halotolerance.
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