ArticlePloS one2009
Association and haplotype analyses of positional candidate genes in five genomic regions linked to scrotal hernia in commercial pig lines.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Investigation of ELF5, KIF18A, NPTX1 and COL23A1 genes in the pathophysiology of indirect inguinal hernia in children.Pediatric surgery international · 2026Article
- The downregulation of genes encoding muscle proteins have a potential role in the development of scrotal hernia in pigs.Molecular biology reports · 2024Article
- Article
- Inguinal Ring RNA Sequencing Reveals Downregulation of Muscular Genes Related to Scrotal Hernia in Pigs.Genes · 2020Article
- Rediscover and Refine QTLs for Pig Scrotal Hernia by Increasing a Specially Designed FFrontiers in genetics · 2019Article
- Genome-wide association study reveals a QTL and strong candidate genes for umbilical hernia in pigs on SSC14.BMC genomics · 2018Article
- Identification of Genetic Regions Associated with Scrotal Hernias in a Commercial Swine Herd.Veterinary sciences · 2018Article
- Screening of BCL-2 associated X protein gene polymorphism associated with scrotal hernia in domesticated swine using polymerase chain reaction-restriction fragment length polymorphism.Asian-Australasian journal of animal sciences · 2017Article
- Article
- Genome-wide association study using deregressed breeding values for cryptorchidism and scrotal/inguinal hernia in two pig lines.Genetics, selection, evolution : GSE · 2015Article
- High incidence of scrotal hernias in a closed colony of FVB mice.Comparative medicine · 2012Article
- Transcriptome analysis and SSR/SNP markers information of the blunt snout bream (Megalobrama amblycephala).PloS one · 2012Article
- Generation of genome-scale gene-associated SNPs in catfish for the construction of a high-density SNP array.BMC genomics · 2011Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scrotal hernia in pigs is a complex trait likely affected by genetic and environmental factors. A large-scale association analysis of positional and functional candidate genes was conducted in four previously identified genomic regions linked to hernia susceptibility on Sus scrofa chromosomes 2 and 12, as well as the fifth region around 67 cM on chromosome 2, respectively. In total, 151 out of 416 SNPs discovered were genotyped successfully. Using a family-based analysis we found that four regions surrounding ELF5, KIF18A, COL23A1 on chromosome 2, and NPTX1 on chromosome 12, respectively, may contain the genetic variants important for the development of the scrotal hernia in pigs. These findings were replicated in another case-control dataset. The SNPs around the ELF5 region were in high linkage disequilibrium with each other, and a haplotype containing SNPs from ELF5 and CAT was highly significantly associated with hernia development. Extensive re-sequencing work focused on the KIF18A gene did not detect any further SNPs with extensive association signals. These genes may be involved in the estrogen receptor signaling pathway (KIF18A and NPTX1), the epithelial-mesenchymal transition (ELF5) and the collagen metabolism pathway (COL23A1), which are associated with the important molecular characteristics of hernia pathophysiology. Further investigation on the molecular mechanisms of these genes may provide more molecular clues on hernia development in pigs.
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