ArticleExperimental & molecular medicine2009
Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis.
Article in Experimental & molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Elevated cytokines in osteoporotic blood correlate with immune microenvironment shifts and dysregulated circRNA profiles.Frontiers in immunology · 2026Article
- Extracellular vesicles from glycolytic mesenchymal stromal cells restrain arthritis progression via IL-10-Producing T and B cells.Theranostics · 2026Article
- Exploring Chronic Pain, Immune Dysfunction and Lifestyle: A Focus on T Cell Exhaustion and Senescence.Biomolecules · 2025Review
- Emerging Therapeutic Targets in Rheumatoid Arthritis: Focusing on HIF-1α, Nrf2, STATs, and RORγt.Current drug targets · 2025Review
- Host and immunosuppression-related factors influencing fibrosis occurrence post liver transplantation.Frontiers in pharmacology · 2022Article
- The protective role of TBX21-1514T>C polymorphism in susceptibility to multiple sclerosis.Iranian journal of neurology · 2018Article
- Evidence for genetic association of TBX21 and IFNG with systemic lupus erythematosus in a Chinese Han population.Scientific reports · 2016Article
- TBX21 polymorphisms are associated with virus persistence in hepatitis C virus infection patients from a high-risk Chinese population.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Polymorphisms of interleukin-31 are associated with anti-CCP levels in females with rheumatoid arthritis.Journal of genetics · 2014Article
- The haplotypes of TNFRSF17 polymorphisms are associated with colon cancer in a Korean population.International journal of colorectal disease · 2012Article
- The role of upstream stimulatory factor 1 in the transcriptional regulation of the human TBX21 promoter mediated by the T-1514C polymorphism associated with systemic lupus erythematosus.Immunogenetics · 2012Article
- Identifying Polymorphisms in IL-31 and Their Association with Susceptibility to Asthma.Korean journal of pathology · 2012Article
- Association between gastric cancer and -1993 polymorphism of TBX21 gene.World journal of gastroenterology · 2012Article
- Genetic associations in acquired immune-mediated bone marrow failure syndromes: insights in aplastic anemia and chronic idiopathic neutropenia.Clinical & developmental immunology · 2012Review
- Association of Paraoxonase 1 (PON1) polymorphisms with osteoporotic fracture risk in postmenopausal Korean women.Experimental & molecular medicine · 2011Article
- Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines.Arthritis and rheumatism · 2009Article
- Identification of DNA methylation associated enrichment pathways in adults with non-specific chronic low back pain.Molecular painArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TBX21 (T-bet) is a member of the T-box family of transcriptional factors that contain a conserved DNA binding domain. TBX21 is a critical regulator of the commitment to the Th1 lineage and IFN-gamma production. Th1 and Th2 cells cross-regulate the differentiation of each other, and in this way TBX21 could be an attractive candidate gene for treating autoimmune disease such as rheumatoid arthritis (RA). In present study, we analyzed the genotypic frequencies of six polymorphisms of the TBX21 gene between the 367 RA patients and the 572 healthy controls. We showed that the g.-1514T>C and c.99C>G polymorphisms are suggestively associated with RA susceptibility. It is interesting that the genotypic frequencies of the TBX21 polymorphisms (g.-1514T>C and c.2103A>C) in the male RA patients were significantly different from the male control group (P=0.0016 and 0.045, respectively). We also found that the g.-1514T>C and c.2103A>C polymorphisms of the TBX21 gene in the male RA patients have significant association with the levels of anti-CCP (P=0.05) and rheumatoid factor (P=0.03), respectively. These results suggest that the polymorphisms of the TBX21 gene might be associated with the susceptibility to male RA patients.
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