ReviewCytogenetic and genome research2008
The evolutionary significance of copy number variation in the human genome.
Review in Cytogenetic and genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Genome wide landscaping of copy number variations for horse inter-breed variability.Animal biotechnology · 2025Article
- Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseases.Cell death & disease · 2025Review
- Demyelination and Remyelination: General Principles.Advances in neurobiology · 2025Review
- Article
- The impact of FASTQ and alignment read order on structural variant calling from long-read sequencing data.PeerJ · 2024Article
- An effect of large-scale deletions and duplications on transcript expression.Functional & integrative genomics · 2022Article
- DNA copy number variation: Main characteristics, evolutionary significance, and pathological aspects.Biomedical journal · 2021Review
- Gene diversity explains variation in biological features of insect killing fungus, Beauveria bassiana.Scientific reports · 2021Article
- Fuzzy methods for the detection of copy number variations in comparative genomic hybridization arrays.Saudi journal of biological sciences · 2020Article
- Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival.Scientific reports · 2020Article
- CNVs are associated with genomic architecture in a songbird.BMC genomics · 2018Article
- Analysis of Copy Number Variation in the Abp Gene Regions of Two House Mouse Subspecies Suggests Divergence during the Gene Family Expansions.Genome biology and evolution · 2017Article
- Salivary Amylase: Digestion and Metabolic Syndrome.Current diabetes reports · 2016Review
- Linking short tandem repeat polymorphisms with cytosine modifications in human lymphoblastoid cell lines.Human genetics · 2016Article
- Rapid and reliable detection of α-globin copy number variations by quantitative real-time PCR.BMC hematology · 2014Article
- Gene copy number variation and its significance in cyanobacterial phylogeny.BMC microbiology · 2012Article
- Mixed sequence reader: a program for analyzing DNA sequences with heterozygous base calling.TheScientificWorldJournal · 2012Article
- A genomic portrait of human microsatellite variation.Molecular biology and evolution · 2011Article
- Ontogenetic variation of the human genome.Current genomics · 2010Article
- Optimizing copy number variation analysis using genome-wide short sequence oligonucleotide arrays.Nucleic acids research · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Copy number variation provides the raw material for gene family expansion and diversification, which is an important evolutionary force. Moreover, copy number variants (CNVs) can influence gene transcriptional and translational levels and have been associated with complex disease susceptibility. Therefore, natural selection may have affected at least some of the greater than one thousand CNVs thus far discovered among the genomes of phenotypically normal humans. While identifying and understanding particular instances of natural selection may shed light on important aspects of human evolutionary history, our ability to analyze CNVs in traditional population genetic frameworks has been limited. However, progress has been made by adapting some of these frameworks for use with copy number data. Moving forward, these efforts will be aided by non-human organism studies of the population genetics of copy number variation, and by more direct comparisons of within-species copy number variation and between-species copy number fixation.
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Registered trials
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