ArticleAmerican journal of physiology. Heart and circulatory physiology2009
Systemic injection of planktonic forms of mammalian-derived nanoparticles alters arterial response to injury in rabbits.
Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Hydroxyapatite as a Vehicle for the Selective Effect of Superparamagnetic Iron Oxide Nanoparticles against Human Glioblastoma Cells.ACS applied materials & interfaces · 2017Article
- Calcifying nanoparticles promote mineralization in vascular smooth muscle cells: implications for atherosclerosis.International journal of nanomedicine · 2014Article
- Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.PloS one · 2013Article
- Quantitative estimates of the variability of in vivo sonographic measurements of the mouse aorta for studies of abdominal aortic aneurysms and related arterial diseases.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2011Article
- Key role of alkaline phosphatase in the development of human-derived nanoparticles in vitro.Acta biomaterialia · 2011Article
- Proteomic evaluation of biological nanoparticles isolated from human kidney stones and calcified arteries.Acta biomaterialia · 2010Article
- Article
- Review
- Characterization of biofilm formed by human-derived nanoparticles.Nanomedicine (London, England) · 2009Article
- Article
- Biologic nanoparticles and platelet reactivity.Nanomedicine (London, England) · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Experiments were designed to test the hypothesis that the systemic delivery of planktonic forms of nanoparticles (NPs) derived from calcified, diseased human tissue or bovine blood are transmissible particles that exacerbate arterial response to injury. New Zealand White rabbits in which the endothelium was mechanically removed from one carotid artery were injected intravenously with either saline (control), lipopolysaccharide (LPS; surrogate for subclinical infection), hydroxyapatite crystals (HA; surrogate for NP shell), HA crystals exposed to culture media, or planktonic forms of bovine- or human-derived NPs. Carotid arteries were monitored by ultrasonography for 5 wk and then removed for histological examination. Uninjured arteries from all animals in each group remained patent with a normal anatomy. Injured arteries from 6 of 11 animals injected with human-derived NPs occluded and/or calcified; none of the injured arteries from animals in the other groups occluded (n = 28; P < or = 0.05). Injured arteries of rabbits injected with LPS or HA crystals developed eccentric hyperplasia. Discontinuous internal elastic laminae and thinning media characterized arteries from animals injected with bovine-derived NPs or cultured HA crystals. In conclusion, the systemic administration of planktonic forms of human-derived NPs exacerbated arterial response to injury distinct from that of bovine-derived NPs and other inflammatory agents.
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