ArticleAmerican journal of physiology. Heart and circulatory physiology2009
Transfer function characteristics of the neural and peripheral arterial baroreflex arcs at rest and during postexercise muscle ischemia in humans.
Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Sex differences in the sympathetic neurocirculatory responses to chemoreflex activation.The Journal of physiology · 2022Trial
- Short-term water deprivation does not increase blood pressure variability or impair neurovascular function in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025Article
- Peripheral chemoreflex restrains skeletal muscle blood flow during exercise in participants with treated hypertension.The Journal of physiology · 2025Article
- Impaired Neurocirculatory Control in Chronic Kidney Disease: New Evidence for Blunted Sympathetic Baroreflex and Reduced Sympathetic Transduction.Function (Oxford, England) · 2024Article
- Sympathetic baroreflex sensitivity is enhanced in postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- CORP: Standardizing methodology for assessing spontaneous baroreflex control of muscle sympathetic nerve activity in humans.American journal of physiology. Heart and circulatory physiology · 2021Article
- Blood pressure responses to dietary sodium: Association with autonomic cardiovascular function in normotensive adults.Autonomic neuroscience : basic & clinical · 2017Article
- Sympathetic function during whole body cooling is altered in hypertensive adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- What is important for aging-induced arterial stiffening, autonomic dysfunction, vascular characteristics or both?Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Impaired dynamic cerebral autoregulation at rest and during isometric exercise in type 2 diabetes patients.American journal of physiology. Heart and circulatory physiology · 2015Article
- Muscle sympathetic nerve activity during cold stress and isometric exercise in healthy older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Blood pressure regulation II: what happens when one system must serve two masters--oxygen delivery and pressure regulation?European journal of applied physiology · 2014Review
- Resting sympathetic baroreflex sensitivity in subjects with low and high tolerance to central hypovolemia induced by lower body negative pressure.Frontiers in physiology · 2014Article
- Elderly blacks have a blunted sympathetic neural responsiveness but greater pressor response to orthostasis than elderly whites.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Influence of age and sex on the pressor response following a spontaneous burst of muscle sympathetic nerve activity.American journal of physiology. Heart and circulatory physiology · 2012Article
- The arterial baroreflex resets with orthostasis.Frontiers in physiology · 2012Article
- Closed-loop spontaneous baroreflex transfer function is inappropriate for system identification of neural arc but partly accurate for peripheral arc: predictability analysis.The Journal of physiology · 2011Article
- Insulin enhances the gain of arterial baroreflex control of muscle sympathetic nerve activity in humans.The Journal of physiology · 2010Article
- Influence of endurance training on central sympathetic outflow to skeletal muscle in response to a mixed meal.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
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Authors and funding
5 authors.
Funding
Abstract
Previous studies have demonstrated an increase in the arterial baroreflex (ABR) control of muscle sympathetic nerve activity (MSNA) during isolated activation of the muscle metaboreflex with postexercise muscle ischemia (PEMI). However, the increased ABR-MSNA control does not appear to manifest in an enhancement in the ABR control of arterial blood pressure (BP), suggesting alterations in the transduction of MSNA into a peripheral vascular response and a subsequent ABR-mediated change in BP. Thus we examined the operating gains of the neural and peripheral arcs of the ABR and their interactive relationship at rest and during muscle metaboreflex activation. In nine healthy subjects, graded isolation of the muscle metaboreflex was achieved by PEMI following isometric handgrip performed at 15% and 30% maximal voluntary contraction (MVC). To obtain the sensitivities of the ABR neural and peripheral arcs, the transfer function gain from BP to MSNA and MSNA to femoral vascular conductance, respectively, was analyzed. No changes from rest were observed in the ABR neural or peripheral arcs during PEMI after 15% MVC handgrip. However, PEMI following 30% MVC handgrip increased the low frequency (LF) transfer function gain between BP and MSNA (ABR neural arc; +58 +/- 28%, P = 0.036), whereas the LF gain between MSNA and femoral vascular conductance (ABR peripheral arc) was decreased from rest (-36 +/- 8%, P = 0.017). These findings suggest that during high-intensity muscle metaboreflex activation an increased ABR gain of the neural arc appears to offset an attenuation of the peripheral arc gain to help maintain the overall ABR control of systemic BP.
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