ArticleAmerican journal of physiology. Heart and circulatory physiology2009
Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.
Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 123 citations in OpenAlex.
- Blood pressure response to controlled diesel exhaust exposure in human subjects.Hypertension (Dallas, Tex. : 1979) · 2012Trial
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- Evaluation of Ambient Ozone Pollution Exposure on Mice Testicular Tissue: An Integrated Metabolomic and Transcriptomic Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Prostaglandin E2 dependent migration of human brain endothelial cells is mediated through Rho-Kinase-II.PloS one · 2025Article
- Ambient Air Pollution Exposure and Adverse Outcomes Among Medicare Beneficiaries With Heart Failure.Journal of the American Heart Association · 2024Article
- Effect of chronic exposure to fine particulate matter on cardiac tissue of NZBWF1 mice.International journal of experimental pathology · 2023Article
- Acute inhalation of tungsten particles results in early signs of cardiac injury.Toxicology letters · 2023Article
- Impact of Intratracheal Administration of Polyethylene Glycol-Coated Silver Nanoparticles on the Heart of Normotensive and Hypertensive Mice.International journal of molecular sciences · 2023Article
- Association between short-term air pollution exposure and traumatic intracranial hemorrhage: pilot evidence from Taiwan.Frontiers in neurology · 2023Article
- Environmental risk factors and cardiovascular diseases: a comprehensive expert review.Cardiovascular research · 2022Article
- Air Pollution and Intracranial Hemorrhage.Annals of Indian Academy of Neurology · 2022Article
- Protective effect of crocin on hemodynamic parameters, electrocardiogram parameters, and oxidative stress in isolated hearts of rats exposed to PMIranian journal of basic medical sciences · 2022Article
- The cardiovascular effects of air pollution: Prevention and reversal by pharmacological agents.Pharmacology & therapeutics · 2022Review
- Exacerbation of Thrombotic Responses to Silver Nanoparticles in Hypertensive Mouse Model.Oxidative medicine and cellular longevity · 2022Article
- Investigation of morphological abnormalities in red blood cells among dental laboratory technicians.Environmental science and pollution research international · 2021Article
- Transcriptomic analysis of key genes and pathways in human bronchial epithelial cells BEAS-2B exposed to urban particulate matter.Environmental science and pollution research international · 2021Article
- Particulate Matter Exposure Exacerbates Amyloid-β Plaque Deposition and Gliosis in APP/PS1 Mice.Journal of Alzheimer's disease : JAD · 2021Article
- Inflammatory effects of particulate matter air pollution.Environmental science and pollution research international · 2020Review
- Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution.Environmental health perspectives · 2020Article
- Oxidative stress and the cardiovascular effects of air pollution.Free radical biology & medicine · 2020Review
8 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to ambient air pollution has been associated with increases in blood pressure. We have previously demonstrated activation of the Rho/Rho kinase pathway in experimental hypertension in rats. In this investigation, we evaluated the effects of particulate matter of < 2.5 microm (PM(2.5)) exposure on cardiovascular responses and remodeling and tested the effect of Rho kinase inhibition on these effects. C57BL/6 mice were exposed to concentrated ambient PM(2.5) or filtered air for 12 wk followed by a 14-day ANG II infusion in conjunction with fasudil, a Rho kinase antagonist, or placebo treatment. Blood pressure was monitored, followed by analysis of vascular function and ventricular remodeling indexes. PM(2.5) exposure potentiated ANG II-induced hypertension, and this effect was abolished by fasudil treatment. Cardiac and vascular RhoA activation was enhanced by PM(2.5) exposure along with increased expression of the guanine exchange factors (GEFs) PDZ-RhoGEF and p115 RhoGEF in PM(2.5)-exposed mice. Parallel with increased RhoA activation, PM(2.5) exposure increased ANG II-induced cardiac hypertrophy and collagen deposition, with these increases being normalized by fasudil treatment. In conclusion, PM(2.5) potentiates cardiac remodeling in response to ANG II through RhoA/Rho kinase-dependent mechanisms. These findings have implications for the chronic cardiovascular health effects of air pollution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.