ArticleAmerican journal of physiology. Heart and circulatory physiology2009
Myocardial oxygenation and functional recovery in infarct rat hearts transplanted with mesenchymal stem cells.
Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
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- Prospective application of stem cells to prevent post-operative skeletal fibrosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Review
- Allogenic Myocytes and Mesenchymal Stem Cells Partially Improve Fatty Rotator Cuff Degeneration in a Rat Model.Stem cell reviews and reports · 2018Article
- The use of stem cells in ischemic heart disease treatment.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2018Review
- Pharmacological Therapy in the Heart as an Alternative to Cellular Therapy: A Place for the Brain Natriuretic Peptide?Stem cells international · 2016Review
- Inhibition of poly (ADP-ribose) polymerase and inducible nitric oxide synthase protects against ischemic myocardial damage by reduction of apoptosis.Molecular medicine reports · 2015Article
- Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells.International journal of clinical and experimental pathology · 2015Article
- HypoxamiR regulation and function in ischemic cardiovascular diseases.Antioxidants & redox signaling · 2014Review
- Reoxygenation-derived toxic reactive oxygen/nitrogen species modulate the contribution of bone marrow progenitor cells to remodeling after myocardial infarction.Journal of the American Heart Association · 2014Article
- Real-time, in vivo determination of dynamic changes in lung and heart tissue oxygenation using EPR oximetry.Advances in experimental medicine and biology · 2014Article
- Noninvasive monitoring of small intestinal oxygen in a rat model of chronic mesenteric ischemia.Cell biochemistry and biophysics · 2013Article
- Endothelial cells overexpressing IL-8 receptor reduce cardiac remodeling and dysfunction following myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2013Article
- Stem cell therapy for cardiovascular disease: the demise of alchemy and rise of pharmacology.British journal of pharmacology · 2013Review
- Human embryonic stem cell derived mesenchymal progenitors express cardiac markers but do not form contractile cardiomyocytes.PloS one · 2013Article
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- Mesenchymal stem cells: from experiment to clinic.Fibrogenesis & tissue repair · 2011Article
- Growth of engineered human myocardium with mechanical loading and vascular coculture.Circulation research · 2011Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Stem cell therapy for myocardial tissue repair is limited by the poor survival of transplanted cells, possibly because of inadequate supply of oxygen and nutrients. The purpose of this study was to assess the oxygenation level and functional recovery after allogenic transplantation of mesenchymal stem cells (MSC) in a rat model of myocardial infarction (MI). Myocardial oxygen tension (Po(2)) was measured by electron paramagnetic resonance oximetry using an implantable oxygen-sensing spin probe (OxySpin). MSCs incubated with OxySpins showed substantial uptake of the probe without affecting its oxygen sensitivity or calibration. The cells internalized with OxySpins were able to differentiate into osteogenic, adipogenic, cardiomyocyte, and endothelial cell lineages. The labeled cells tested positive for CD44 and CD29 markers and negative for the hematopoietic markers CD14 and CD45. For the in vivo studies, MI was induced in rats by permanently ligating the left anterior descending coronary artery. MSCs with OxySpins were transplanted in the infarct region of hearts. A significant increase in Po(2) was observed in the MSC group compared with the untreated MI group (18.1 +/- 2.6 vs. 13.0 +/- 1.8 mmHg, n = 4, P < 0.05) at 4 wk after transplantation. Echocardiography showed a significant improvement in ejection fraction and fraction shortening, which inversely correlated with the magnitude of fibrosis in the treated hearts. The cell-transplanted hearts also showed an increase in vascular endothelial growth factor level and capillary density in the infarct region. The study established our ability to measure and correlate changes in myocardial tissue oxygenation with cardiac function in infarcted rat hearts treated with MSCs.
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