ArticleAmerican journal of physiology. Lung cellular and molecular physiology2009
A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice.
Article in American journal of physiology. Lung cellular and molecular physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Association between asthma and cardiovascular diseases: A longitudinal follow-up study using a national health screening cohort.The World Allergy Organization journal · 2024Article
- Extracellular Vesicles and Asthma-More Than Just a Co-Existence.International journal of molecular sciences · 2021Review
- Imbalanced Coagulation in the Airway of Type-2 High Asthma with Comorbid Obesity.Journal of asthma and allergy · 2021Review
- The Ratio of Factor VIIa:Tissue Factor Content within Microvesicles Determines the Differential Influence on Endothelial Cells.TH open : companion journal to thrombosis and haemostasis · 2019Article
- Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM).American journal of obstetrics and gynecology · 2018Article
- Are pulmonary hemostasis and fibrinolysis out of balance in equine chronic pneumopathies?Journal of veterinary science · 2017Article
- IL-13 Augments Compressive Stress-Induced Tissue Factor Expression in Human Airway Epithelial Cells.American journal of respiratory cell and molecular biology · 2016Article
- Chronic Rhinosinusitis and the Coagulation System.Allergy, asthma & immunology research · 2015Review
- Characterization of coagulation factor synthesis in nine human primary cell types.Scientific reports · 2012Article
- Upregulation of the coagulation factor VII gene during glucose deprivation is mediated by activating transcription factor 4.PloS one · 2012Article
- Tissue factor in predicted severe acute pancreatitis.World journal of gastroenterology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Eosinophil counts in the bronchoalveolar lavage fluid of wild-type (WT) mice increased after ovalbumin (OVA) challenge, a response that was diminished in comparably challenged low-expressing coagulation factor VII (FVII(tTA/tTA)) mice. Levels of T helper type 2 (Th2) cytokines, IL-4, IL-5, and IL-13, and eosinophil-attracting chemokines, eotaxin and RANTES, were also lower in the OVA-challenged FVII(tTA/tTA) mice. Eosinophils purified from low-FVII mice underwent apoptosis at a faster rate compared with WT eosinophils, and eosinophil migration in response to eotaxin was reduced in eosinophils obtained from FVII(tTA/tTA) mice. Airway hyperresponsiveness and mucous layer thickness were reduced in OVA-treated FVII(tTA/tTA) mice, and addition of exogenous coagulation factor X (FX) enhanced mucin production in human epithelial NCI-H292 cells. Correspondingly, incubation of FX with NCI-H292 cells resulted in activated (a) FX production, suggesting that the components required for FX activation were present on NCI-H292 cells. These results demonstrate that FVIIa functions in the asthmatic response to an allergen by stimulating lung eosinophilia, airway hyperresponsiveness, and mucin production, this latter effect through its ability to activate FX in conjunction with tissue factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.